血清抗C1q抗体在系统性红斑狼疮及狼疮性肾炎中的临床诊断价值  

The Clinical Diagnostic Value of Serum Anti-C1q Antibody Level in SLE and LN Patients

作　　者：张小云[1] 姜玉章[1] 唐朝贵[1] 张迎梅[1] 刘蓓蓓[1] 连建春 ZHANG Xiao-yun;JIANG Yu-zhang;TANG Chao-gui(The Affiliated Huaian No.1 People,s Hospital of Nanjing Medical University,223300)

机构地区：[1]南京医科大学附属淮安第一医院

出　　处：《临床输血与检验》2019年第6期582-585,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：南京医科大学科技发展基金（No.2016NJMU144）资助

摘　　要：目的探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清抗C1q抗体与疾病活动及狼疮性肾炎(lupus nephritis,LN)的相关性.方法采用ELISA法测定110例SLE患者和60例正常对照组血清中抗C1q抗体的水平.110例SLE患者按LN判定标准分为LN组(41例)和非LN组(69例).比较分析其与补体C3、C4、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)及疾病活动性指标抗双链DNA(anti-double-stranded DNA antibody,anti-dsDNA)抗体的相关性,并通过联合检测抗核小体抗体(anti-nucleosome antibodies,AnuA)及抗dsDNA抗体判断其在LN中的临床价值.结果SLE患者中血清抗C1q抗体水平高于正常对照组[(11.90±23.83)U/mL vs(2.73±4.18)U/mL,P<0.05].LN患者血清中抗C1q抗体水平与抗dsDNA抗体、hs-CRP水平呈显著正相关,与补体C3、C4含量水平呈显著负相关.联合检测抗C1q抗体、抗dsDNA抗体和AnuA显著提高LN的诊断价值.结论抗C1q抗体水平能反映SLE的疾病活动程度,并与SLE肾损害相关,联合检测抗C1q抗体、抗dsDNA抗体和AnuA有助于LN的诊断.Objective To detect the associations between anti-C1q antibody and systemic lupus erythematosus(SLE)and that between anti-C1q antibody and lupus nephritis(LN).Methods The Anti-C1q antibody were measured using ELISA kit from 110 cases of SLE patients(SLE group)and 60 cases of healthy people(normal control group).The 110 SLE patients were divided into LN group with 41 patients and non LN group with 69 patients.The serum levels of Anti-C1q,anti-dsDNA antibody and biochemical markers of the two groups were detected,and the result were analyzed.Results The serum anti-C1q antibody level of SLE group was significantly higher than that of normal control group[(11.90±23.83)U/mL vs(2.73±4.18)U/mL,P<0.05].Serum level of anti-C1q antibody in LN group showed a strongly positive correlation with anti-dsDNA antibody and showed a negative correlation with C3 and C4 level.Conclusion Anti-C1q antibody would be helpful to characterize the disease activity of SLE,and is associated with SLE kindey damage.The combined detection of serum anti-C1q antibody,AnuA and anti-dsDNA antibody can improve LN diagnostic specificity.

关 键 词：抗C1Q抗体 系统性红斑狼疮 狼疮性肾炎 

分 类 号：R446.11[医药卫生—诊断学] R593.24[医药卫生—临床医学]