紫癜性肾炎患儿血清APN、CysC、OPN 和IgA1水平分析  

An Analysis of Serum Concentrations of APN,CysC,OPN and IgA1 in Children with Henoch Schonlein Purpura Nephritis

作　　者：袁婷婷 张锐锋 商巧雨 YUAN Ting-ting;ZHANG Rui-feng;SHANG Qiao-yu(Pediatric Hospital of Xuzhou,Jiangsu,221000)

机构地区：[1]江苏省徐州市儿童医院

出　　处：《临床输血与检验》2019年第6期623-626,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨血清脂联素(APN)、胱抑素C(CysC)、骨桥蛋白(OPN)、免疫球蛋白A1(IgA1)水平在紫癜性肾炎(HSPN)患儿中的水平及相关性.方法选择2015年3月~2017年3月科室收治的紫癜性肾炎患儿39例,设为HSPN组;选择同期入院健康体检者50例,设为对照组,采用酶联免疫吸附试验测定2组APN、CysC、OPN、IgA1水平;分析HSPN发生率与APN、CysC、OPN、IgA1水平的相关性.结果HSPN组血清脂联素水平,低于对照组(P<0.05);HSPN组胱抑素C、骨桥蛋白及免疫球蛋白A1水平,均高于对照组(P<0.05);HSPN患儿发生率与血清APN呈负相关性(P<0.05);HSPN患儿发生率与CysC、OPN、IgA1呈正相关(P<0.05).结论血清APN、CysC、OPN、IgA1的检测在HSPN的发生发展过程中发挥重要作用,有助于了解疾病严重程度,能为临床治疗提供依据和参考,值得推广应用.Objective To investigate the concentrations of serum adiponectin(APN),cystatin C(CysC),osteopontin(OPN)and immunoglobulin A1(IgA1)in children with purpura nephritis and explore their significance in the diagnosis of the disease.Methods Thirty-nine children who received treatments in the hospital during the past two years were selected as HSPN group and 50 healthy subjects were enrolled in parallel.Enzyme-linked immunosorbent assay was used to detect the levels of APN,CysC,OPN and IgA1 in the two groups.The incidence of HSPN and the concentrations of APN,CysC,OPN and IgA1 were analyzed by SPSS Pearson correlation analysis software.Results Serum adiponectin in HSPN group was lower than that in control group(P<0.05).The levels of cystatin C,osteopontin and immunoglobulin A1 in HSPN group significantly increased(P<0.05).The incidence of HSPN was negatively correlated with the serum APN(P<0.05),but positively correlated with the concentrations of CysC,OPN,and IgA1(P<0.05).Conclusion Detection of serum APN,CysC,OPN and IgA1 is useful in assessment of occurrence,progress and severity of the disease.

关 键 词：过敏性紫癜 紫癜性肾炎 脂联素 胱抑素C 骨桥蛋白 免疫球蛋白A1 

分 类 号：R554[医药卫生—血液循环系统疾病] R446.11[医药卫生—内科学]