安徽地区42 509名未成年人乙肝病毒血清标志物的调查  

Evaluation of Serum Biomarkers of Hepatitis B Virus Among 42 509 Young Adults in Anhui Province

作　　者：朱丽娟 郝家砚 许莉莉 李林 ZHU Li-juan;HAO Jia-yan;XU Li-li(Department of Clinical Laboratory,Anhui Provincial Children's Hospital,Hefei 230051)

机构地区：[1]安徽省儿童医院检验科

出　　处：《临床输血与检验》2019年第6期646-649,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的分析0~17岁不同年龄区间的未成年人体内乙肝病毒血清标志物,探讨乙肝疫苗的免疫效果和加强免疫的必要性.方法收集2018年就诊于安徽省儿童医院42509位患儿的血清,采用化学发光方法对乙型肝炎HBsAg和HBsAb定量检测,分析未成年人乙肝病毒携带情况及疫苗接种效果分析.结果经统计42509位0~17岁未成年人血清检测结果,发现HBsAg阳性者37例,占0.087%.HBsAb总阳性率71.33%,其中1~2岁的群体抗体阳性率最高,为93.41%;3岁以后HBsAb阳性率逐渐下降;儿童从出生至7个月后,抗体浓度≥100 mIU/mL的人数比例从34.21%显著提高到88.05%;从4~6岁人群开始至18岁人群抗体浓度≥100 mIU/mL的人数比例基本保持在80%左右.结论安徽地区未成年人乙肝病毒携带率较低;安徽地区的乙肝疫苗接种的效果较好,学龄前儿童可再次检测抗体浓度,必要时可加强免疫.Objective To evaluate the long term effect of Hepatitis B vaccination by analyzing the serum biomarkers among 0-17 year old children and young adults,so as to determine the necessity of booster vaccination.Method Quantitative analyses of serum HBsAg and HBsAb were performed in 42905 children and young adults in the hospital.Results Thirty seven(0.087%)children and young adults showed positive HBsAg and 71.33%of them demonstrated positive HBsAb,with 93.41%in 1~2 year old babies but gradual decrease with age.The percentage of the subjects with the concentration of HBsAb over 100 mIU/mL increased from 34.21%in one-month old babies to 88.05%in 7-month ones.Nearly 80%of the subjects from the ages of 4~6 years to 18 years presented the stable level of HBsAg.Conclusions The prevalence of hepatitis B virus infection in children and young adults in Anhui is low.Serum HBsAg retest is helpful for evaluating the necessity of HB booster vaccination in preschool children and young adults.

关 键 词：乙肝病毒 未成年人 乙肝病毒疫苗 

分 类 号：R179[医药卫生—妇幼卫生保健] R373.2[医药卫生—公共卫生与预防医学]