胆康胶囊对胆结石伴胆囊炎术后患者胆道内环境及炎性因子的影响  

Effect of Dankang Capsules on Biliary Internal Environment and Inflammatory Factors in Patients with Gallstone Complicated with Cholecystitis After the Operation

作　　者：李旭彤[1] 石庆龙[1] 曹双军[1] 齐富贵 LI Xutong;SHI Qinglong;CAO Shuangjun;QI Fugui(Department of General Surgery,Liangxiang Hospital of Beijing Fangshan District,Beijing,China 102401)

机构地区：[1]北京市房山区良乡医院普通外科

出　　处：《中国药业》2019年第24期55-57,共3页China Pharmaceuticals

基　　金：首都卫生发展科研专项[首发2014-3-7041]

摘　　要：目的探讨胆康胶囊对胆结石伴胆囊炎术后患者胆道内环境及炎性因子的影响。方法选取医院2014年5月至2017年12月收治的胆结石伴胆囊炎患者98例,按随机数字表法分为对照组和治疗组,各49例。两组患者均予腹腔镜下胆道镜取石术,术后口服甲硝唑片及熊去氧胆酸片,治疗组患者加服胆康胶囊,均连续治疗4周。结果治疗组总有效率为89.80%,明显高于对照组的67.35%(P<0.05);治疗后,两组患者总胆汁酸(TBA)水平均明显高于治疗前,间接胆红素(UCB)、钙离子(Ca2+)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均明显低于治疗前,且治疗组上述指标改善程度均明显优于对照组(P<0.05);治疗组患者抗菌药物使用时间、术后排气时间及术后排便时间均明显短于对照组(P<0.05);治疗过程中,治疗组与对照组不良反应发生率相当(16.33%比20.41%,P>0.05)。结论胆结石伴胆囊炎术后给予胆康胶囊,能改善患者的胆道内环境,降低炎性因子水平。Objective To investigate the effect of Dankang Capsules on biliary internal environment and inflammatory factors in patients with gallstone complicated with cholecystitis after the operation.Methods Totally 98 patients with gallstone complicated with cholecystitis admitted to our hospital from May 2014 to December 2017 were selected and divided into the control group and treatment group according to the random number table method,49 cases in each group.The patients in the two groups were given laparoscopic choledochoscopic lithotripsy treatment,and they were given Metronidazole Tablets and Ursodeoxycholic Acid Tablets after the operation.On this basis,the patients in the treatment group were given Dankang Capsules.Both groups were continuously treated for 4 weeks.Results The total effective rate of the treatment group was 89.80%,which was significantly higher than 67.35%of the control group(P<0.05).After treatment,the level of total bile acid(TBA)in the two groups was significantly higher than that before treatment,while the levels of unconjugated bilirubin(UCB),calcium ion(Ca2+),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were significantly lower than those before treatment,and the improvement of the above indexes in the treatment group was significantly better than that in the control group(P<0.05).The duration of antibiotics consumption,postoperative exhaust time and postoperative defecation time in the treatment group were significantly shorter than those in the control group(P<0.05).The incidence of adverse reactions in the two groups was similar during the treatment(16.33%vs.20.41%,P>0.05).Conclusion Dankang Capsules in the treatment of patients with gallstone complicated with cholecystitis after the operation can improve the biliary internal environment and reduce the level of inflammatory factors.

关 键 词：胆结石 胆囊炎 胆康胶囊 胆道内环境 炎性因子 

分 类 号：R969.4[医药卫生—药理学] R2-031[医药卫生—药学]