母乳喂养联合母乳强化剂在早产极低出生体质量儿喂养中的应用观察  

Application of breastfeeding combined with addition of human milk fortifier in the feeding of premature infants with very low birth weight

作　　者：冯欢欢[1] 刘小亮 FENF Huanhuan;LIU Xiaoliang(Neonates Department,Xi′an Gaoxin Hospital,Xi′an,Shaanxi,710068)

机构地区：[1]陕西省西安高新医院新生儿科

出　　处：《实用临床医药杂志》2019年第22期107-109,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨母乳喂养联合母乳强化剂在早产极低出生体质量儿喂养中的应用效果。方法选取80例出生体质量极低的早产儿,按随机数字表法分为对照组与观察组,各40例。对照组采用常规母乳喂养,观察组在此基础上添加母乳强化剂。观察2组早产儿在喂养前与喂养2个月后的发育情况(身长、体质量、头围)、血清骨代谢指标[钙(Ca)、磷(P)、碱性磷酸酶(ALP)]、甲状腺指标[促甲状腺激素(TSH)、甲状腺激素(T4)、三碘甲状腺原氨酸(T 3)]、免疫功能[T淋巴细胞亚群(CD3^+、CD4^+、CD4^+/CD8^+)、血清免疫球蛋白IgA含量]的水平变化。结果喂养2个月后,2组出生体质量极低的早产儿头围、身长、体质量较喂养前显著增加(P<0.05),血清Ca、ALP、T4、T3、IgA与T淋巴细胞亚群水平均较喂养前显著升高(P<0.05),P、TSH水平均较喂养前显著下降(P<0.05),且观察组上述各指标均较对照组变化更显著(P<0.05)。结论母乳喂养联合母乳强化剂可促进早产极低出生体质量儿的生长发育及骨骼钙化,提高甲状腺功能,增强免疫力。Objective To explore the application of breastfeeding combined with addition of human milk fortifier in the feeding of premature infants with very low birth weight.Methods Eighty premature infants with very low birth weight in our hospital were enrolled.They were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was fed with conventional breast milk,and observation group was added human milk fortifier.The developmental status(body length,body weight,head circumference),and serum bone metabolism indexes[calcium(Ca),phosphorus(P),alkaline phosphatase(ALP)],thyroid indexes[thyroid stimulating hormone(TSH),thyroid hormone(T 4),triiodothyronine(T 3)],immune function[T lymphocyte subsets(CD3^+,CD4^+,CD4^+/CD8^+),serum immunoglobulin(IgA)]were observed among premature infants with very low birth weight in the two groups before feeding and after 2 months of feeding.Results After 2 months of feeding,the head circumference,body length and body weight and levels of serum Ca,ALP,T 4,T 3,IgA and T lymphocyte subsets of premature infants with very low birth weight were significantly increased compared with those before feeding(P<0.05),while the P and TSH levels were decreased compared with those before feeding(P<0.05).The changes of the above indexes in observation group were obvious than those in control group(P<0.05).Conclusion Addition of human milk fortifier in breastfeeding can promote the growth and development and bone calcification,improve thyroid function and increase immunity of premature infants with very low birth weight.

关 键 词：母乳喂养 母乳强化剂 早产儿 极低出生体质量儿 

分 类 号：R816.92[医药卫生—放射医学]