鲑鱼降钙素对绝经后妇女骨质疏松性桡骨远端骨折术后疼痛及骨密度的影响分析  

Effect of salmon calcitonin on postoperative pain and bone mineral density in postmenopausal women with osteoporotic distal radius fracture

作　　者：李洪秋[1] 邓纯博[1] 东黎阳[1] 阿良[1] DONG Li-yang;A Liang(Central Hospital of Shenyang Medical College,Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院

出　　处：《实用药物与临床》2019年第12期1266-1268,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨鲑鱼降钙素对绝经后妇女骨质疏松性桡骨远端骨折患者术后镇痛效果及骨密度的影响。方法纳入2017年1月至2018年12月在我院住院并行手术的72例绝经后女性患者,按性别相同、年龄相近、骨折部位和类型相同、身高和体重相近、骨折复位固定方法相同的原则进行匹配,将患者分为研究组和对照组,每组36例。研究组给予鲑鱼降钙素和口服钙尔奇D,对照组仅给予口服钙尔奇D,两组给药时间均为3个月;采用视觉模拟量表(VAS)评估患者疼痛程度,采用双能X线进行骨密度检测。结果术后1周时,研究组、对照组患者VAS评分比较差异无统计学意义(8.1±0.4 vs.8.6±0.4,P>0.05);术后3周时,研究组患者VAS评分低于对照组(5.3±0.3 vs.7.2±0.4,P<0.01)。术后6周时,研究组、对照组患者VAS评分比较差异无统计学意义(2.3±0.5 vs.3.1±0.3,P>0.05)。研究组、对照组患者术前腰椎和股骨颈骨密度比较差异无统计学意义[(0.69±0.23)g/cm^2 vs.(0.72±0.16)g/cm^2,(0.61±0.36)g/cm^2 vs.(0.68±0.12)g/cm^2,P>0.05];术后3个月时,研究组患者腰椎和股骨颈骨密度均高于对照组[(0.98±0.43)g/cm^2 vs.(0.83±0.21)g/cm^2,(0.92±0.52)g/cm^2 vs.(0.73±0.31)g/cm^2,P<0.01]。结论鲑鱼降钙素对绝经后妇女骨质疏松性桡骨远端骨折患者术后早期有明显的镇痛作用,也可提高绝经后妇女腰椎及股骨颈骨密度。Objective To investigate the effect of salmon calcitonin on postoperative analgesia and bone mineral density in postmenopausal women with osteoporotic distal radius fracture.Methods A total of 72 postmenopausal women who were hospitalized and operated in our hospital from January 2017 to December 2018 were included.According to the principles of the same gender,and the similar age,fracture site and type,height and weight,and fracture reduction and fixation method,the patients were divided into study group and control group,36 cases in each group.Study group was given salmon calcitonin and calcium D orally,while the control group was only given calcium D orally,both groups were treated for 3 months.Visual analogue scale(VAS)was used to evaluate the degree of pain and dual energy X-ray was used to detect the bone mineral density.Results At 1 week after operation,there was no significant difference in the VAS between the two groups(8.1±0.4 vs.8.6±0.4,P>0.05);at 3 weeks after operation,the VAS in study group was lower than that in control group(5.3±0.3 vs.7.2±0.4,P<0.01).There was no significant difference in the VAS between the two groups at 6 weeks after operation(2.3±0.5 vs.3.1±0.3,P>0.05).There was no significant difference in bone mineral density of lumbar vertebra and femoral neck between the two groups before operation[(0.69±0.23)g/cm^2 vs.(0.72±0.16)g/cm^2,(0.61±0.36)g/cm^2 vs.(0.68±0.12)g/cm^2,P>0.05];at 3 months after operation,the bone mineral density of lumbar vertebra and femoral neck in study group was higher than that in control group[(0.98±0.43)g/cm^2 vs.(0.83±0.21)g/cm^2,(0.92±0.52)g/cm^2 vs.(0.73±0.31)g/cm^2,P<0.01].Conclusion Salmon calcitonin has a significant analgesic effect during the early postoperative period in postmenopausal women with osteoporotic distal radius fracture,and can also improve the bone density of lumbar vertebrae and femoral neck in postmenopausal women.

关 键 词：骨质疏松性骨折 鲑鱼降钙素 桡骨远端骨折 

分 类 号：R68[医药卫生—骨科学]