不同年龄段妊娠期糖尿病孕妇血小板和凝血参数变化特点及对母儿近期并发症影响  

Changes of Platelet and Coagulation Indexes in Pregnant Women with Gestational Diabetes Mellitus at Different Ages and Effect on the recent complications of mother and infant

作　　者：朱怡恬 孙慧谨[1] 汪晓曼 项兰兰 程峰[1] Zhu Yitian;Sun Huijin;Wang Xiaoman;Xiang Lanlan;Cheng Feng(Clinical Laboratory,Women’s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing,210004,China)

机构地区：[1]南京医科大学附属妇产医院检验科

出　　处：《现代仪器与医疗》2019年第6期49-52,共4页Modern Instruments & Medical Treatment

摘　　要：目的:比较分析妊娠期糖尿病(GDM)孕妇不同年龄段血小板和凝血参数的变化特点。方法:随机抽取GDM组孕妇395例和正常组孕妇471例,两组孕妇再分为三个年龄段组:≤29岁组,30~34岁组,≥35岁以上组。检测孕妇外周血的血小板计数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、纤维蛋白原(FIB)等,以及围产期胎膜早破、羊水过少、胎儿窘迫等不良并发症资料的收集。结果:GDM孕妇与正常孕妇PT、FIB和MPV之间差异有统计学意义(P<0.05)。GDM孕妇与正常孕妇各年龄段各参数之间存在差异:≤29岁GDM孕妇FIB、MPV与正常组孕妇相比差异有统计学意义(P<0.05),30~34岁GDM孕妇FIB与正常组孕妇相比差异有统计学意义(P<0.05),≥35岁GDM孕妇PT与正常组孕妇相比差异有统计学意义(P<0.05)。GDM孕妇与正常孕妇参数异常率中FIB异常率差异有统计学意义(P<0.05)。≤29岁和30~34岁GDM孕妇FIB异常率显著高于相应年龄组正常孕妇,≥35岁GDM孕妇与对照组相比差异没有统计学意义(P>0.05)。GDM孕妇和正常孕妇围产期胎膜早破、羊水过少、胎儿窘迫不良并发症的发生差异无统计学意义(P>0.05)。结论:GDM孕妇血小板和凝血参数与正常孕妇相比部分参数差异有统计学意义。GDM孕妇部分参数在30岁左右就存在显著变化。做好妊娠期糖尿病孕妇的孕期保健,可减少妊娠不良结局。Objective:Compere the changes of platelet and coagulation indexes in different age groups of pregnant women with gestational diabetes mellitus(GDM).Methods:395 pregnant women in GDM group and 471 pregnant women in normal group.The two groups of pregnant women were further divided into three age groups:group≤29 years old,group 30-34 years old and group≥35 years old.Platelet count(PLT),mean platelet volume(MPV),platelet dwastribution width(PDW),thrombin time(TT),prothrombin time(PT),activated partial thrombin time(APTT),fibrinogen(FIB).of peripheral blood of pregnant women were detected,as well as the collection of data on adverse complications such as premature rupture of fetal membranes,oligohydramnios,fetal dwastress,etc.Results:There were significant differences in PT,FIB and MPV between GDM pregnant women and normal pregnant women(P<0.05).There were differences between GDM pregnant women and normal pregnant women in all ages:FIB and MPV of GDM pregnant women≤29 years old were significantly different from normal pregnant women,FIB of GDM pregnant women aged 30-34 years old were significantly different from normal pregnant women,PT of GDM pregnant women≥35 years old were significantly different from normal pregnant women(P<0.05).The FIB abnormal rates of GDM pregnant women and normal pregnant women was significantly different(P<0.05).The abnormal rate of FIB of GDM pregnant women≤29 years old and 30-34 years old was significantly higher than that of normal pregnant women in the corresponding age group(P<0.05).There was no significant difference between GDM pregnant women≥35 years old and those≥35 years old(P>0.05).There was no significant difference between GDM pregnant women and normal pregnant women in the incidence of perinatal premature rupture of membranes,oligohydramnios and adverse complications of fetal dwastress.Conclusion:Platelet and coagulation indexes of GDM pregnant women were significantly different from those of normal pregnant women.Some parameters of pregnant women with GDM change

关 键 词：妊娠期糖尿病 妊娠晚期 血小板功能 凝血功能 

分 类 号：R714[医药卫生—妇产科学]