高脂血症激化椎间盘退变的影像学研究  

The imaging study of hyperlipidemia induced disc degeneration

作　　者：张月东[1] 王玫 赵建 尚凯[1] 赵亮[1] ZHANG Yue-dong;WANG Mei;ZHAO Jian;SHANG Kai;ZHAO Liang(Dept.of Orthopaedics,Taian Central Hospital,Taian 271000,China;Shandong First Medical University(Shandong Medical College),Taian 271016,China)

机构地区：[1]泰安市中心医院骨科,山东泰安271000 [2]山东第一医科大学(山东省医科院),山东泰安271016

出　　处：《泰山医学院学报》2019年第12期888-890,共3页Journal of Taishan Medical College

基　　金：山东省医药卫生科技发展计划项目(编号:2018WS146);泰安市科技发展计划项目(编号:2018NS0163)

摘　　要：目的探讨高脂血症与MRI椎间盘退变程度的相关性。方法选取单节段腰椎间盘突出手术患者140例,分为实验组和对照组,行MRI椎间盘退变分级比较。实验组纳入高脂血症患者70名,包括50名男性和20名女性,平均年龄41.39岁(22~64岁);对照组纳入正常血脂患者70名,包括46名男性和24名女性,平均年龄41.04岁(22~68)岁。结果两组患者在年龄与性别上相匹配;MRI影像学比较,两组之间椎间盘突出节段无明显差(P=0.374);Modic影像学分级比较,两组之间终板退变无明显差异(P=0.534);Pfirrman影像学分级比较,高脂血症患者的椎间盘退变程度比正常血脂患者更加严重(P<0.001)。结论高脂血症有可能加重椎间盘退变,加速椎间盘病理状态的发展。Objective:To investigate the relationship between dyslipidaemia and the MRI degree of intervertebral disc degeneration(IVDD).Methods:A total of 140 patients underwent surgery for single-level lumbar disc herniation were recruited for this study,and the MRI comparison of disc degeneration was performed.The experimental group included 70 patients with hyperlipidaemia(50 men and 20 women;mean age:41.39 years),while the control group included 70 patients with hyperlipidaemia(46 men and 24 women;mean age:41.04 years).Results:No differences were found in gender and age between cases and controls.Hyperlipidaemia did not seem to be associated with the herniated segment of the lumbar intervertebral disc(P=0.374)and the grades of cartilage endplate degeneration(P=0.534).However,the degenerative degree in hyperlipidemia group was more serious than control(P<0.001).Conclusions:Hyperlipidaemia resulted in an exaggerated degenerative changes,these results raise the possibility that hyperlipidaemia may accelerate the progression of disc degeneration.

关 键 词：高脂血症 椎间盘退变 MRI加权像 动脉粥样硬化 

分 类 号：R68[医药卫生—骨科学]