生物膜、毒力基因和耐药基因对APEC的致病性作用  

Pathogenic effects of biofilm,virulence genes and drug resistance genes on APEC

作　　者：卢琴[1] 罗青平[1] 张腾飞[1] 罗玲[1] 汪宏才[1] 王红琳[1] 温国元[1] 张蓉蓉[1] 张文婷 邵华斌[1] LU Qin;LUO Qing-ping;ZHANG Teng-fei;LUO Ling;WANG Hong-cai;WANG Hong-lin;WEN Guo-yuan;ZHANG Rong-rong;ZHANG Wen-ting;SHAO Hua-bin(Institute of Animal Husbandry and Veterinary,Hubei Academy of Agricultural Scinences/Key Laboratory of Prevention and Control Agents for Animal Bacteriosis,Wuhan 430064,China)

机构地区：[1]湖北省农业科学院畜牧兽医研究所/农业部畜禽细菌病防治制剂创制重点实验室

出　　处：《湖北农业科学》2019年第23期132-135,共4页Hubei Agricultural Sciences

基　　金：国家重点研发计划项目（2016YFD0501305）;现代农业产业技术体系建设专项（CARS-42-G13）;农业部重点实验室基金项目（KLPCAAB-YTP-1803）;湖北省农业科技创新中心项目（2016-620-004-003）;湖北省技术创新专项（2018ABA108)

摘　　要：禽致病性大肠杆菌病(Avian Pathogenic Escherichia coli,APEC)是危害养禽业发展的主要细菌性病原之一,给养禽业的发展带来了严重危害。为研究APEC的致病性与耐药性之间的关系,从毒力基因的分布、生物膜的形成能力、耐药基因的分布等三个方面探讨了生物膜的形成能力与毒力基因、耐药基因在致病性中的作用,为后期研究禽大肠杆菌的致病机理及耐药机制等提供理论基础,并为开展禽大肠杆菌病的流行病学调查及监测、防控禽大肠杆菌病的流行提供理论数据。Avian Pathogenic Escherichia coli(APEC) is one of the major bacterial pathogens that endangers the development of the poultry industry, and has brought serious harm to the development of the poultry industry. In order to study the relationship between pathogenicity and drug resistance of APEC,the distribution of virulence genes, the biofilm formation ability and the distribution of drug resistance genes were discussed from three aspects,which were the distribution of virulence gene, the ability of biofilm formation and the distribution of drug resistance gene. The results provided a theoretical basis for the later study of the pathogenic mechanism and drug resistance mechanism of avian Escherichia coli, and carried out epidemiological investigation and surveillance of avian colibacillosis, and provided theoretical data for the prevention and control of avian Escherichia coli.

关 键 词：禽致病性大肠杆菌病(Avian Pathogenic Escherichia coli APEC) 生物膜 毒力基因 耐药基因 致病性 

分 类 号：R378.21[医药卫生—病原生物学]