基于星形胶质细胞的脑缺血损伤治疗研究进展  

Research Progress in Treatment of Cerebral Ischemia Injury Based on Astrocytes

作　　者：魏珍珍[1] 方晓艳[1] 白明[1] 苗明三[1] WEI Zhen-zhen;FANG Xiao-yan;BAI Ming;MIAO Ming-san(Henan University of Chinese Medicine,Zhengzhou,450046,China)

机构地区：[1]河南中医药大学

出　　处：《神经药理学报》2019年第1期36-43,共8页Acta Neuropharmacologica

基　　金：国家重大新药创制项目（No.2009ZX09103-324）;河南省科技攻关项目（No.152102310103、No.152102410049）

摘　　要：星形胶质细胞是人脑内数量最多的细胞,在缺血早期结构会发生明显变化,表达多种神经营养因子和损伤因子,对缺血呈高度的敏感性,可以作为判断早期缺血的一个指标。近年来对星形胶质细胞在脑缺血中的作用特点的研究有很大的进展,星形胶质细胞对脑缺血具有双重作用,可通过多种途径影响受损脑组织。但是,星形胶质细胞在脑缺血后的作用机制尚不明确,如何通过调控星形胶质细胞促进脑损伤神经功能的恢复,这给脑缺血的治疗和新药研发带来新的方向和挑战。Astrocytes are the largest number of cells in the human brain,and their structures will change significantly in the early stage of ischemia.They express many neurotrophic factors and injury factors and are highly sensitive to ischemia,which can be used as an index to judge early ischemia.In recent years,great progress has been made in the study of the characteristics of astrocytes in cerebral ischemia.Astrocytes have dual effects on cerebral ischemia and can affect damaged brain tissues through various ways.However,the mechanism of action of astrocytes after cerebral ischemia is still unclear.How to control astrocytes to promote the recovery of neural function after brain injury has brought new directions and challenges to the treatment of cerebral ischemia and the development of new drugs.

关 键 词：星形胶质细胞 脑缺血 作用机制 药物靶点 

分 类 号：R964[医药卫生—药理学]