生物活性玻璃骨材料力学性能及成骨作用改性的研究进展  

Mechanical Property and Osteogenesis Bioactivity Improvement of Bioactive Glass as Bone Graft Substitutes: a Review

作　　者：杨立[1] 汪鹏生 张浩[1] 王丰[1] 杨雄刚 冯江涛 华堃池 胡永成[3] YANG Li;WANG Pengsheng;ZHANG Hao;WANG Feng;YANG Xionggang;FENG Jiangtao;HUA Kunchi;HU Yongcheng(Tianjin Medical University,Tianjin 300070;The Wei Dafeng Biological Materials Company in Beijing,Beijing 101102;Tianjin Hospital,Tianjin 300211)

机构地区：[1]天津医科大学,天津300070 [2]北京威达峰生物材料有限公司,北京101102 [3]天津市天津医院,天津300211

出　　处：《材料导报》2019年第S02期553-558,共6页Materials Reports

摘　　要：骨科手术在进行骨缺损修复重建时,往往需要将具有良好生物活性及生物相容性的骨移植材料填充到缺损处,在机体内环境下,骨移植材料发生降解并释放相关生物活性介质,促进成骨细胞增殖、分化,最终诱导并促进骨组织形成。其中生物活性玻璃具有良好的生物活性、生物相容性及可降解性,被广泛应用于牙科、骨科及药物载体等方面,但存在脆性大、易断裂及强度低等不足,限制了其在较大骨缺损及承重骨部位修复中的应用。因此,对生物活性玻璃进行改性已成为材料学研究的方向之一。本文主要从调节玻璃组成、多种材料复合及优化制备工艺等方面,总结了改善生物活性玻璃力学性能及促进成骨作用的方法。Bone graft materials which can induce and promote the bone regeneration have always been applied to replace damaged parts of the bone.Among these bone graft materials,bioactive glass is one sort of bioactive materials with high biological activity,biocompatibility and biodegradability.However,because of its fragility,breaking tenacity and low mechanical strength compared with normal bone tissue,there remains limitations when applying bioactive glass for repairment of long load-bearing and large area bone defect.And the current article focuses on deve-lopment and perspectives to improve the mechanical property and osteogenesis bioactivity of bioactive glass including regulating the component of it,recombining with other materials and improving the preparation technology.

关 键 词：生物玻璃 玻璃组分 复合材料 制备工艺 溶胶-凝胶法 

分 类 号：R318[医药卫生—生物医学工程]