针刺联合颈痛颗粒治疗神经根型颈椎病及对患者IL-6、TNF-α、IL-1β和血液流变学指标的影响  

Acupuncture combined with Jingtong granule for nerve-root type cervical spondylosis and its effects on IL-6、TNF-α、IL-1β and hemorheological indexes

作　　者：潘胜莲[1] 郑士立[1] 周夏慧 王庆来[1] PAN Sheng-lian;ZHENG Shi-li;ZHOU Xia-hui;WANG Qing-lai(Department of Acupuncture and Moxibustion,Wenzhou Hospital of TCM,Wenzhou 325000,Zhejiang Province,China)

机构地区：[1]温州市中医院针灸科

出　　处：《中国针灸》2019年第12期1274-1278,共5页Chinese Acupuncture & Moxibustion

基　　金：浙江省中医药管理局项目：2019ZB122

摘　　要：目的:探讨针刺联合颈痛颗粒治疗神经根型颈椎病的临床疗效及对患者血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)水平和血液流变学指标的影响。方法:将114例神经根型颈椎病患者随机分为观察组和对照组,每组57例。两组均采用牵引治疗。对照组口服颈痛颗粒,每次4g,每天3次;观察组在对照组治疗基础上结合针刺治疗,穴取大椎、天柱、后溪、颈椎夹脊穴、曲池、合谷、外关,每天1次。两组疗程均为4周。观察两组治疗前后简化Mc Gill疼痛问卷(simplified McGill pain questionnaire,MPQ)、颈部残障指数(neck disability index,NDI)、麻木评分,血清IL-6、TNF-α、IL-1β及血液流变学水平变化,并比较两组临床疗效。结果:观察组总有效率为91.2%(52/57),高于对照组的71.9%(41/57,P<0.05)。两组治疗后MPQ、NDI和麻木评分均较治疗前降低(P<0.05);观察组治疗后MPQ、NDI和麻木评分低于对照组(P<0.05)。治疗后两组血清IL-6、TNF-α和IL-1β水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后两组血浆黏度、纤维蛋白原、全血黏度低切和全血黏度高切水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。结论:针刺联合颈痛颗粒治疗神经根型颈椎病临床疗效显著,可降低患者血清IL-6、TNF-α和IL-1β水平,改善血液流变学。Objective To explore the clinical efficacy of acupuncture combined with Jingtong granule for nerve-root type cervical spondylosis and its effects on serum interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β)and hemorheological indexes.Methods A total of 114 patients with nerve-root type cervical spondylosis were randomly divided into an observation group and a control group,57 cases in each group.The patients in both groups were treated with traction.The patients in the control group were treated with oral administration of Jingtong granule,4 g each time,3 times a day,while based on the treatment of control group,the patients in the observation group were treated with acupuncture at Dazhui(GV 14),Tianzhu(BL 10),Houxi(SI 3),cervical Jiaji(EX-B 2),Quchi(LI 11),Hegu(LI 4)and Waiguan(TE 5),once a day.Both groups were treated for 4 weeks.The simplified McGill pain questionnaire(MPQ),neck disability index(NDI),numbness score,levels of IL-6,TNF-α,IL-1β in serum and hemorheological indexes were observed before and after treatment,and the clinical efficacy was compared between the two groups.Results The total effective rate was 91.2%(52/57)in the observation group,which was higher than 71.9%(41/57)in the control group(P<0.05).Compared before treatment,the scores of MPQ,NDI and numbness in the two groups were reduced after treatment(P<0.05).After treatment,the scores of MPQ,NDI and numbness in the observation group were lower than those in the control group(P<0.05).After treatment,the serum levels of IL-6,TNF-α and IL-1β in the two groups were reduced(P<0.05),and those in the observation group were lower than the control group(P<0.05).After treatment,the plasma viscosity,fibrinogen,low shear rate of whole blood viscosity and high shear rate of whole blood viscosity in the two groups were lower than before treatment(P<0.05),and those in the observation group were lower than the control group(P<0.05).Conclusion Acupuncture combined with Jingtong granule have significant clinical efficacy for

关 键 词：神经根型颈椎病 针刺 颈痛颗粒 白介素-6 肿瘤坏死因子-α 白介素-1Β 血液流变学 

分 类 号：R246.6[医药卫生—针灸推拿学]