PD-L1在结直肠癌组织中的表达及临床意义  

Expression of PD-L1 and its clinical significance in colorectal cancer

作　　者：杜舟[1] 黄萍[2] 黄国裕 韩少良[3] 左志贵[4] DU Zhou;HUANG Ping;HUANG Guoyu;HAN Shaoliang;ZUO Zhigui(Department of Hernia and Abdominal Wall Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China;Office of Development and Planning,Wenzhou Medical University,Wenzhou 325035,China;Department of Gastrointestinal Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China;Department of Colorectal Anal Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China)

机构地区：[1]温州医科大学附属第一医院疝与腹壁外科,浙江温州325015 [2]温州医科大学发展规划处,浙江温州325035 [3]温州医科大学附属第一医院胃肠外科,浙江温州325015 [4]温州医科大学附属第一医院结直肠肛门外科,浙江温州325015

出　　处：《温州医科大学学报》2020年第1期41-44,共4页Journal of Wenzhou Medical University

基　　金：温州市公益性科技计划项目（2017Y1031）

摘　　要：目的:观察程序性死亡配体-1(PD-L1)在结直肠癌组织及癌旁组织中的表达,探索其与患者临床病理特征之间的相关性,并探讨PD-L1表达水平在结直肠癌中的临床意义。方法:选取2016年1月至2017年1月温州医科大学附属第一医院50例结直肠癌患者,手术中获取癌组织及癌旁组织,采用PCR及Western blot检测结直肠癌及癌旁组织中PD-L1 mRNA及蛋白水平,并分析其与临床病理特征之间的相关性。结果:与癌旁组织相比,结直肠癌组织中PD-L1基因及蛋白表达量均显著升高(P<0.05)。癌组织中PD-L1蛋白阳性率与癌组织分化程度和淋巴转移相关(P<0.05)。结论:PD-L1在结直肠癌组织中表达增高,并与结直肠癌患者的临床病理特征密切相关。Objective:To investigate the expression of PD-L1 in colorectal cancer and its relationship with clinicopathologic features,and meanwhile to discuss the clinical significance of PD-L1 expression.Methods:Colorectal cancer tissues and adjacent normal tissues were obtained from 50 patients with colorectal cancer.RTPCR and Western blot were conducted to detect the expression of PD-L1 in mRNA and protein levels.Results:The expression of PD-L1 in colorectal cancer tissues was elevated,compared with that in adjacent normal tissues(P<0.05).The elevated expression of PD-L1 in colorectal cancer tissues was correlated with cancer differentiation degree and lymphatic metastasis(P<0.05).Conclusion:PD-L1 was highly expressed in colorectal cancer patients,which was correlated with the clinicopathologic features.

关 键 词：结直肠癌 程序性死亡配体-1 癌旁组织 免疫逃逸 

分 类 号：R656[医药卫生—外科学]