血府逐瘀颗粒治疗UAP合并心力衰竭的疗效及对CPP、CysC、hs-CRP、BNP的影响  

Therapeutic Effect of Xuefu Zhuyu Granule on Unstable Angina Pectoris Combined with Heart Failure and its Effect on CPP,CysC,hsCRP,BNP Levels

作　　者：刘榕 刘明春[1] 唐耀华[1] LIU Rong;LIU Mingchun;TANG Yaohua(Panzhihua Integrated Traditional Chinese and Western Medicine Hospital,Panzhihua 617000,Sichuan,China)

机构地区：[1]攀枝花市中西医结合医院

出　　处：《中西医结合心脑血管病杂志》2019年第22期3550-3553,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨血府逐瘀颗粒治疗不稳定型心绞痛(UAP)合并心力衰竭的疗效及对超声心动图相关指标、胱抑素C(CysC)、和肽素(CPP)、血浆超敏C反应蛋白(hs-CRP)及脑钠肽(BNP)的影响。方法选取我院2016年1月-2017年12月收治的160例UAP合并心力衰竭病人,随机分为观察组和对照组,各80例。观察组给予常规西药和血府逐瘀颗粒治疗,对照组仅给予常规西药治疗。观察两组左心室射血分数(LVEF)、心排血量(CO)、CPP、CysC、hs-CRP及BNP水平。结果治疗前两组心绞痛发作持续时间及频率比较,差异无统计学意义(P>0.05);与治疗前相比,治疗后两组心绞痛发作频率显著降低,持续时间显著缩短;观察组心绞痛发作频率明显低于对照组,发作时间也明显短于对照组,差异均有统计学意义(P<0.05)。治疗前两组LVEF和CO比较,差异无统计学意义(P>0.05);治疗后两组LVEF、CO水平明显高于治疗前,且观察组明显高于对照组,差异有统计学意义(P<0.05)。治疗前两组CPP、CysC、hs-CRP、BNP表达水平比较,差异无统计学意义(P>0.05);与治疗前相比,治疗后两组CPP、CysC、hs-CRP、BNP水平显著降低,且观察组降低更明显,差异有统计学意义(P<0.05)。结论血府逐瘀颗粒治疗UAP合并心力衰竭可以有效升高LVEF和CO,降低血清CPP、CysC、hs-CRP及BNP水平,降低心绞痛发作频率,缩短心绞痛发作持续时间。Objective To explore the efficacy of Xuefu Zhuyu Granule in treating unstable angina pectoris(UAP) combined with heart failure and its effects on echocardiography-related indicators,cystatin C(CysC),Copeptin(CPP),and plasma hypersensitive C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP).Methods One hundred and sixty UAP patients with heart failure who were treated in our hospital from January 2016 to December 2017 were chosen,and were randomly divided into the observation group and the control group,with 80 cases in each group.The patients in observation group was treated with conventional western medicine and Xuefu Zhuyu Granules,while the patients in control group was treated with conventional western medicine.The left ventricular ejection fraction(LVEF),cardiac output(CO),CPP,CysC,hs-CRP,and BNP levels were observed in the two groups.Results There were no significant differences in the duration and frequency of angina pectoris in the two groups before treatment(P>0.05).Compared with data before treatment,the frequency of angina pectoris in two groups was significantly reduced and the duration was significantly reduced after treatment.The frequency was significantly lower than that in control group,and the attack time was also significantly shorter than that in control group(P<0.05).There was no significant differences in LVEF and CO between the two groups before treatment(P> 0.05),and the levels of LVEF and CO in two groups after treatment were significantly higher than that before treatment,and that in observation group was significantly higher than that in control group(P<0.05).There were no significant differences in the the levels of CPP,CysC,hs-CRP,and BNP between two groups before treatment(P>0.05).Compared with data before treatment,the levels of CPP,CysC,hs-CRP,and BNP were significantly reduced in two groups after treatment.And the reduction in the observation group was more obvious(P<0.05).Conclusion Xuefu Zhuyu Granules could effectively increase LVEF and CO,reduce serum CPP,CysC,hs-CRP

关 键 词：不稳定型心绞痛 心力衰竭 血府逐瘀颗粒 和肽素 胱抑素C 超敏C反应蛋白 脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病] R256.2[医药卫生—内科学]