3D打印技术在药物递送中的应用（英文）  

3D printing technology in drug delivery system

作　　者：郝文艳 李瑞滕[1,3] 杜丽娜 金义光 HAO Wen-yan;LI Rui-teng;DU Li-na;JIN Yi-guang(Department of Pharmaceutical Sciences,Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;Weifang Medical University,Weifang 261000,China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]军事科学院军事医学研究院辐射医学研究所,北京100850 [2]潍坊医学院,潍坊261000 [3]山东中医药大学,济南250355

出　　处：《国际药学研究杂志》2019年第10期725-737,共13页Journal of International Pharmaceutical Research

摘　　要：3D打印是一种基于数字模型文件的快速成型技术,它采用黏附性材料(如粉末状金属或塑料)逐层打印。3D打印技术由于优势众多而在药剂学领域引起关注,如操作简便、弹性好、重复性高、通用型强,最重要的是能满足个体化需求。目前,3D打印已用于药物速释、缓释、植入等。采用3D打印将医疗器械与药物结合实现药械一体化成为研究热点。本综述概括了有关3D打印技术、材料和剂型的最新进展,分析了其优势与局限性,为3D打印技术在药物递送中的应用和发展提供参考。3D打印技术的药物递送系统将为个体化给药注入新鲜活力。Three-dimensional(3D)printing,a type of rapid prototyping technology,is based on a digital model file and prints layer-by-layer using adhesive materials,such as powdered metal or plastic.3D printing has attracted much attention in the pharmaceutical field because of the various advantages,such as simple operation,good flexibility,high repeatability,wide adaptability,and more importantly,customized service.Currently,it is used in formulations of immediate release,sustained release,implants,etc.Recently,the integration of medical devices and drugs with 3D printing has been gaining popularity.This review not only summarizes the latest progress in techniques,materials,and pharmaceutical dosage forms used in drug delivery system with 3D printing,but also analyzes its advantages and limitations,with the hope of providing reference for the development and application of 3D printing technology in drug delivery.This novel drug delivery system will bring new vitality to individualized medication.

关 键 词：3D打印 药物递送 个体化治疗 水凝胶 栓剂 

分 类 号：R943.4[医药卫生—药剂学] R9-39[医药卫生—药学]