河南省汉族儿童哮喘易感基因多态性分布特征分析  

Distribution characteristics of polymorphisms of asthma susceptibility genes in ethnic Han children in Henan province

作　　者：黄玲玲 彭韶[1] HUANG Ling-ling;PENG Shao(Department of pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450018,China)

机构地区：[1]郑州大学第一附属医院儿科

出　　处：《河南医学研究》2019年第24期4432-4436,共5页Henan Medical Research

摘　　要：目的研究河南地区汉族儿童哮喘易感基因多态性的频率分布特点,为本地区哮喘的个体化治疗提供新的理论基础。方法选择2018年10月至2019年4月于郑州大学第一附属医院门诊确诊的506例哮喘患儿,并收集其颊黏膜脱落细胞。对IL-13 A2044G、IL-4 C590T、ADRB2 R16G、FcεRIβE237G这4种哮喘相关基因位点进行检测,统计分析河南地区汉族儿童哮喘基因多态性的频率分布特点,并检索中外文数据,对河南省ADRB2 R16G基因型频率与其他地区数据比较,作进一步分析。结果河南省汉族儿童的IL-13 A2044G位点AA、AG和GG基因型频率分别为12.6%、44.7%和42.7%,IL-4 C590T位点TT、CT和CC的基因型频率分别为63.1%、31.4%和5.5%,ADRB2 R16G位点AA、AG和GG基因型频率分别为30.4%、50.4%和19.2%,FcεRIβE237G位点AA、AG和GG基因型频率分别为72.1%、24.7%和3.2%。河南地区与南京、贵州、保山地区ADRB2 R16G基因型频率分别比较,差异无统计学意义(均P>0.05);河南省ADRB2 R16G基因型频率与毛里求斯印第安相比,差异有统计学意义(P<0.05)。结论河南省汉族儿童IL-13、IL-4、ADRB2、FcεRIβ基因多态性频率有其自身一定特点,IL-4 C590T位点的风险基因型(TT)在河南省比例最高;ADRB2基因型的分布在不同地域、种族中可能存在差异。Objective To study the frequency distribution characteristics of asthma susceptible gene polymorphism in Han children in Henan province,and to provide a new theoretical basis for individualized treatment of asthma in Henan province.Methods Five hundred and six children with asthma diagnosed in the First Affiliated Hospital of Zhengzhou University from October 2018 to April 2019 were selected and their buccal mucosa exfoliated cells were collected.Four asthma related gene loci,IL-13 A2044G,IL-4 C590T,ADRB2 R16G and FcεRIβE237G were detected.The frequency distribution characteristics of asthma gene polymorphism in Han children in Henan province were statistically analyzed,and the Chinese and foreign data were searched.The frequency of ADRB2 R16G genotype in Henan Province was compared with that in other areas.Results Henan province Han nationality children IL-13 A2044G AA,AG and GG genotype frequency were 12.6%,44.7%and 42.7%,IL-4 C590T TT,CT and CC genotype frequency were 63.1%,31.4%and 5.5%,ADRB2 R16G AA,AG and GG genotype frequency were 30.4%,50.4%and 19.2%,FcεRIβE237G AA,AG and GG genotype frequency were 72.1%,24.7%and 3.2%,respectively.There was no significant difference in the frequency of ADRB2 R16G genotype between Henan region,Nanjing,Guizhou and Baoshan region(all P>0.05).There was a statistically significant difference in the frequency of ADRB2 R16G genotype between Henan province and Mauritius Indian(P<0.05).Conclusion The polymorphic frequencies of IL-13,IL-4,ADRB2 and FcεRIβgenes in Han children in Henan province have their own characteristics.The risk genotype(TT)of IL-4 C590T locus was the highest in Henan province.The distribution of ADRB2 genes may be different in different regions and races.

关 键 词：哮喘 ADRB2基因 IL-13基因 IL-4基因 FcεRIβ基因 

分 类 号：R725.6[医药卫生—儿科]