无金属催化快速合成2-芳酰氨基萘并[1,2-d]噻唑  

Metal-Free Rapid Synthesis of 2-Aroylamino Naphtho[1,2-d]thiazoles

作　　者：刘天宝[1] 彭艳芬[1] 桂美芳[1] 章敏 Liu Tianbao;Peng Yanfen;Gui Meifang;Zhang Min(Key Laboratory of Micro-nano Powder and Advanced Energy Materials of Anhui Higher Education Institutes,Department of Chemical and Material Engineering,Chizhou University,Chizhou,Anhui 247000)

机构地区：[1]池州学院化学与材料工程学院微纳粉体与先进能源材料安徽普通高校重点实验室

出　　处：《有机化学》2019年第11期3199-3206,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21271035);安徽省自然科学基金(No.1808085QB48);安徽省有机化学省级教学团队(No.2017jxtd051)资助项目~~

摘　　要：报道了在室温条件下,二醋酸碘苯促进3-[1-(4-取代萘基)]-1-芳酰基硫脲自身关环得到一系列2-芳酰氨基萘并[1,2-d]噻唑衍生物.该方法具有反应条件温和,反应迅速,操作简单,原子利用率高,无需金属催化以及底物范围广等优点.该方法也为萘并[1,2-d]噻唑衍生物的合成提供了新的高效途径.A novel and efficient approach has been developed to synthesize 2-aroylamino naphtho[1,2-d]thiazole compounds through the reaction between 3-[1-(4-substituted naphthyl)]-1-aroylthiourea and iodosobenzene diacetate(IBD) under ambient air. A library of naphtho[1,2-d]thiazole derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a metal-free synthesis, broad substrate scope, easily accessible reactants,excellent regioselectivity, room temperature reaction conditions under ambient air. The reported method is the efficient approach for the synthesis of naphtho[1,2-d]thiazole derivatives.

关 键 词：萘并[1 2-d]噻唑 硫脲 二醋酸碘苯 无金属催化 

分 类 号：O62[理学—有机化学]