Pd（OAc）2/CuI分步催化合成多取代3-烃硫（硒）基吲哚化合物（英文）  

Pd（OAc）2/Cu I-Catalyzed Tandem Reaction for Synthesis of Polysubstituted 3-Chalcogenylindoles

作　　者：刘瑞婷[1] 李振 王圣克 周锡庚[1,2] Liu Ruiting;Li Zhen;Wang Shengke;Zhou Xigeng(Department of Chemistry,Fudan University,Shanghai 200438;State Key Laboratory of Organometallic Chemistry、Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences Shanghai 200032)

机构地区：[1]复旦大学化学系,上海200438 [2]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海20032

出　　处：《有机化学》2019年第11期3215-3222,共8页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.21572034,21732007,21871054)~~

摘　　要：发展了一种Pd(OAc)2/CuI分步催化2-(2,2-二溴乙烯基)胺、苯硼酸和联硫(硒)化合物发生偶联/环化/硫烷基化反应合成3-烃硫(硒)基吲哚化合物的新方法.底物中不同的官能团,如甲氧基、氯、三氟甲基在反应中都能很好地兼容.Tandem Pd(OAc)2/CuI catalyzed coupling/cyclization/chalcogenylation reaction of gem-dibromovinylanilines with boronic acids and dichalcogenides has been developed, which provides a new synthetic approach to 3-sulfenyl-and 3-selenylindoles. Various functional groups such as methoxyl, halides and trifluoromethyl groups in the substrates are tolerated.

关 键 词：吲哚 Pd(OAc)2/CuI 催化 合成 

分 类 号：O62[理学—有机化学]