三乙胺促进的α-卤代酮C—C键断裂:合成α-乙酰氧基芳基酮（英文）  

Triethylamine Promoted the C—C Bond Cleavage of α-Halo Ketones: α-Acetoxyaryl Ketone Synthesis

作　　者：王毛锐 吴雨峥 姚健 邓黎 潘英明[1] 黄克斌[1] 唐海涛 Wang Maorui;Wu Yuzheng;Yao Jian;Deng Li;Pan Yingming;Huang Kebin;Tang Haitao(State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin,Guangxi 541004)

机构地区：[1]广西师范大学化学与药学院药物资源化学与分子工程国家重点实验室

出　　处：《有机化学》2019年第11期3223-3229,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(No.21362002);the Bagui Scholar Program of Guangxi Province of China(No.2016A13)~~

摘　　要：C-C键断裂在有机合成中有着重要的作用.报道了一种胺促进的α-卤代酮化合物C-C键断裂的新方法,该方法无需使用过渡金属催化剂以及氧化剂.采用这种方法以廉价的α-卤代酮化合物制备了多种α-乙酰氧基芳基酮化合物.The cleavage of C-C bonds is a key method for synthesis of useful intermediates. A novel amine-promoted C-C bond cleavage of α-halo ketones was reported. Oxidant-free and metal-free conditions are the striking features of the protocol. In this simple method, a variety of α-acetoxyaryl ketone compounds were prepared from commercially available α-halo ketones in good to excellent yields.

关 键 词：C-C键的断裂 α-卤代酮 无氧化剂和无金属合成 α-乙酰氧基芳基酮 

分 类 号：O62[理学—有机化学]