基于聚类分析和关联分析的卡培他滨相关手足综合征的中药用药规律研究  

Study on the regularity of traditional Chinese medicine for hand and foot syndrome caused by capecitabine based on cluster analysis and association analysis

作　　者：张静怡 崔慧娟 彭艳梅[1] 李嫱[1] 申文[1] 张旭[1] 孙晨耀 Zhang Jingyi;Cui Huijuan;Peng Yanmei;Li Qiang;Shen Wen;Zhang Xu;Sun Chenyao(Beijing University of Chinese Medicine,Beijing 100029;China-Japan Friendship Hospital)

机构地区：[1]北京中医药大学,北京100029 [2]中曰友好医院

出　　处：《现代中医临床》2019年第6期12-19,共8页Modern Chinese Clinical Medicine

基　　金：国家自然科学基金项目(No.81873396)，中日友好医院院级课题项目(No.2016-2-QN-16)

摘　　要：目的分析中药防治卡培他滨相关手足综合征的用药规律,以指导临床用药。方法检索中国期刊全文数据库、万方医学网、PubMed等数据库,分别筛选中药外用、内服防治卡培他滨相关手足综合征的临床研究类文章,对外用、内服中药分别从使用频次、功效、药性和药味、归经等方面进行统计,并对高频中药进行聚类分析和关联分析。结果纳入文献46篇,涉及方剂39首,用法分为外用、内服2种。外用中药方剂21首,以黄芪桂枝五物汤出现频次最多,80味中药纳入统计,使用频次较高的中药为红花、当归、桂枝、赤芍。内服中药方剂21首,补阳还五汤出现频次最多,70味中药纳入统计,使用频次最高的中药为当归、川芎。外用中药中清热药所占比例最大,为21.3%,内服中药中补虚药所占比例最大,为25.7%。外用和内服中药均以药性为温性者最多,分别占41.3%和45.7%。外用中药中出现频次较高的药味分别是苦味、辛味、甘味,三者之和占89.3%,内服中药出现频次较高的药味分别是甘味、辛味、苦味,三者之和占88.5%。外用和内服中药均以归肝经者最多,分别占17.4%和20.6%。对高频用药进行聚类分析和关联分析,高频外用中药和内服中药均可形成3个聚类方,高频外用中药可得出10对高频药物组合,高频内服中药可得出11对高频药物组合。结论使用中药防治卡培他滨相关手足综合征时,外用中药多用清热、活血化瘀类药物,内服中药则以补虚、清热、活血化瘀药物为主。高频中药聚类分析和关联分析的结果,可以为临床用药提供一定的参考和指导。Objective To analyze the regularity of traditional Chinese medicine in preventing capecitabinerelatedhand and foot syndrome in order to guide clinical medication. Methods The database of ChinaNational Knowledge Infrastructure ,Wanfang Data and PubMed were searched. The clinical research articleson the prevention and treatment of capecitabine-related hand and foot syndrome by external or oral use oftraditional Chinese medicine were screened. The frequency of use of different traditional Chinesemedicines, efficacy, xing, wei, and meridian attribution were analyzed. Cluster analysis and associationanalysis were carried out for high frequency traditional Chinese medicines. Results Forty-six literatures were included, involving 39 decoctions, which were divided into external use and internal use. Among 21decoctions for external use, Huangqi Guizhi Wuwu Decoction was the most frequently used, and 80traditional Chinese medicines were included in the statistics. The most frequently used traditional Chinesemedicines were Honghua, Sanggui, Guizhi and Chishao. Among 21 decoctions for internal use, thefrequency of Buyang Huanwu Decoction was the highest, and 70 traditional Chinese medicines wereincluded in the statistics. The most frequently used was Danggui and Chuanxiong. The proportion of heatclearingdrugs in external Chinese medicines was the largest (21.3 % ) , and the proportion of deficiencytonifyingdrugs in oral Chinese medicines was the largest (25.7% ). The most common property of Chinesemedicines for external use and internal use were both mild property, accounting for 41.3 % and 45. 7 %respectively. The higher frequencies of flavors of external Chinese medicines are bitter, hot and sweet, thesum of which is 89. 3 % . The higher frequencies of flavors of internal Chinese medicines are sweet, hot andbitter, the sum of which is 88.5%. The most common meridian of Chinese medicines for external use andinternal use was both liver meridian, accounting for 17.4% and 20.6% respectively. Cluster analysis andassociation ana

关 键 词：手足综合征 卡培他滨 中医药 用药规律 聚类分析 关联分析 

分 类 号：R273[医药卫生—中西医结合]