新生儿听力筛查通过率与ABO血型系统相关性的临床观察  

Clinical observation of the relationship between the newborn hearing screening and ABO blood groups

作　　者：李霭峰 高国强[2] 牛永芝 付涛[1] 张晓雯[1] 纪彩丽 LI Aifeng;GAO Guoqiang;NIU Yongzhi;FU Tao;ZHANG Xiaowen;JI Caili(Department of Otolaryngology Head and Neck Surgery,the Affiliated Hospital of Qingdao University,Qingdao,266000,China;Department of Obstetrics,the Affiliated Hospital of Qingdao University)

机构地区：[1]青岛大学附厲医院耳鼻咽喉头颈外科,山东青岛266000 [2]青岛大学附属医院产科

出　　处：《临床耳鼻咽喉头颈外科杂志》2019年第11期1049-1052,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨足月新生儿自发性耳声发射(SOAE)和畸变产物耳声发射(DPOAE)通过率与ABO血型系统之间的关系。通过记录SOAE和DPOAE振幅变化,比较4种血型(A型、B型、AB型、O型)听力正常人群的耳声发射结果,分析其差异。方法:随机纳入足月新生儿80名(160耳)为研究对象,4种血型受试者各20名,分别测试双耳SOAE和DPOAE。以反应峰值高于本底噪声3 dB作为SOAE检出标准。取DPOAE中f2的793、1 257、1 587 Hz作为测试频率,f2/f1=1.22。以DPOAE振幅大于本底噪声3 dB为引出标准。结果:O型血受试者SOAE引出率最低(A=70%,B=80%,AB=67%,O=25%)。卡方检测分析4种血型受试者SOAE引出率差异有统计学意义[χ~2(3,n=160)=11.58,P=0.009]。组间比较SOAE引出率差异有统计学意义。O型与A型[χ~2(1,n=80)=5.12,P=0.024];O型与B型[χ~2(1,n=80)=10.453,P=0.001];O型与AB型[χ~2(1,n=80)=4.114,P=0.043]。O型血受试者DPOAE振幅左耳和右耳793、1 257、1 587 Hz与其他受试者相比差异有统计学意义。左耳:793 Hz[F(3,76)=2.779,P=0.047];1 257 Hz[F(3,76)=9.396,P=0.001];1587 Hz[F(3,76)=10.247,P=0.002]。右耳:793 Hz[F(3,76)=2.77,P=0.04];1 257 Hz[F(3,76)=9.428,P=0.02];1 587 Hz[F(3,76)=10.247,P=0.001]。组间比较B型血在793、1 257、1 587 Hz DPOAE振幅要高于O型血(P=0.035;P=0.001;P=0.002)。结论:在足月新生儿中O型血人群SOAE引出率最低,O型血人群双耳DPOAE在793、1 257、1 587 Hz的振幅幅度最小。Objective: To analyze the relationship between ABO blood groups and otoacoustic emissions in full-term newborns, including the occurrence of SOAE and the amplitudes of DPOAE. Method: A total of eighty normal hearing female neonates were included in the study, with equal number of participants in each of the ABO blood group. Measurements of SOAE and DPOAE were collected from both ears of all participants. Result: The blood group O subjects showed significantly fewer SOAE occurrences and lower DPOAE amplitudes at 793 Hz, 1 257 Hz and 1 587 Hz than subjects with other three blood groups both in the left and right ears. Conclusion: The full-term neonates with blood group O have lower SOAE occurrence than other three blood group individual. The blood group O individuals have the lowest amplitude at 793 Hz, 1 257 Hz and 1 587 Hz of both ears.

关 键 词：ABO血型系统 自发性耳声发射 畸变产物耳声发射 噪声性聋 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]