tsRNA研究进展与展望  

Progress and Prospect in tsRNA Research

作　　者：谭冬梅 谭毅 段恩奎[2] TAN Dong-Mei;TAN Yi;DUAN En-Kui(Laboratory Animal Center,Chongqing Medical University,Chongqing 400016,China;State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China)

机构地区：[1]重庆医科大学实验动物中心,重庆400016 [2]中国科学院动物研究所干细胞与生殖生物学国家重点实验室,北京100101

出　　处：《生物化学与生物物理进展》2019年第11期1063-1072,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金（31601206,31671568,31171436）资助项目~~

摘　　要：tRNA-derived small RNAs (tsRNA)是近年来发现的、存在于多种生物体内的一类非编码小RNA,来源于成熟t RNA或tRNA前体,其表达和修饰具有组织和细胞特异性. tsRNA参与应激反应、蛋白质翻译调控、核糖体生物合成、肿瘤发生、细胞增殖与凋亡、表观遗传信息的跨代传递等多种生理和病理过程.本文主要对tsRNA的生成及分类、已知的生物学功能及作用机理、tsRNA及其修饰在疾病中的作用等进行了综述.tRNA-derived small RNAs(tsRNAs) is a type of newly discovered non-coding small RNA, which is derived from mature tRNA or tRNA precursor and exists in various organisms. tsRNAs exhibit tissue-and cellspecific expression and are involved in various biological functions such as stress response, protein translation regulation, ribosomes biogenesis, intergenerational transmission of acquired epigenetic information, tumorgenesis,cell proliferation and apoptosis. This review briefly discussed the biogenesis, classification, biological functions and molecular mechanisms of tsRNAs, as well as the roles of tsRNA modifications in tsRNA regulation and in diseases diagnosis.

关 键 词：tsRNA RNA修饰 蛋白质翻译 转座子 生物学标志物 RNA测序 

分 类 号：Q7[生物学—分子生物学] Q5