丙戊酸钠注射液与氟哌啶醇注射液治疗不伴有精神病性症状双相障碍躁狂发作激越症状的临床研究  

Clinical trial of sodium valproate injection and haloperidol injection in the treatment of acute agitatin of bipolar manic episode without psychotic symptoms

作　　者：魏昆岭[1] 李钊 桑文华[1] 严保平[1] 孙秀丽[1] WEI Kun-ling;LI Zhao;SANG Wen-hua;YAN Bao-ping;SUN Xiu-li(Department of Psychiatry y The Sixth People’s Hospital of Hebei Province,Baoding 071000,Hebei Province,China;Department of Psychiatry,Cangzhou Anding Hospital,Cangzhou 061500,Hebei Province,China)

机构地区：[1]河北省第六人民医院精神科,河北保定071000 [2]沧州安定医院精神科,河北沧州061500

出　　处：《中国临床药理学杂志》2019年第23期3006-3008,3012,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的比较丙戊酸钠注射液和氟哌啶醇注射液治疗不伴有精神病性症状双相障碍躁狂发作急性期激越症状的临床疗效及安全性。方法将70例不伴有精神病性症状双相障碍躁狂发作急性期激越症状患者随机分为对照组和试验组,每组35例。对照组给予氟哌啶醇注射液每次5 mg,早、晚肌内注射1次;试验组予以丙戊酸钠注射液每次0.8 g,qd,静脉点滴。2组患者均治疗3 d。比较2组患者的临床疗效和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为91.18%(31例/34例)和93.75%(30例/32例),差异无统计学意义(P>0.05)。试验组发生的药物不良反应主要有恶心呕吐、头昏和嗜睡;对照组发生的药物不良反应主要有肌强直、静坐不能、心动过速、头昏、恶心呕吐和血压降低。试验组和对照组的总药物不良反应发生率分别为29.41%(10例/34例)和56.25%(18例/32例),差异有统计学意义(P<0.05)。结论丙戊酸钠注射液与氟哌啶醇注射液治疗不伴有精神病性症状双相障碍躁狂发作急性期激越的临床疗效相当,但前者的安全性更高。Objective To compare the clinical efficacy and safety of sodium valproate injection and haloperidol injection in the treatment of acute agitatin of bipolar manic episode without psychotic symptoms.Methods A total of 70 patients with acute agitatin of bipolar manic episode without psychotic symptoms were randomly divided into control and treatment groups with 35 cases per group.Control group was treated with haloperidol injection 5 mg per time,every morning and evening,intramuscular injection.Treatment group was given sodium valproate injection0.8 g per time,qd,intravenous drip.Two groups were treated for 3 days.The clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 91.18%(31 cases/34 cases)and 93.75%(30 cases/32 cases)without significant difference(P>0.05).The adverse drug reactions of treatment group were nausea and vomiting,dizziness and lethargy,which in control group were musclerigidity,akathisia,tachycardia,dizziness,nausea and vomiting and decreased blood pressure.The total incidences of adverse drug reactions in the treatment and control groups were 29.41%(10 cases/34 cases)and 56.25%(18 cases/32 cases)with significant difference(P<0.05).Conclusion The clinical efficacy of sodium valproate injection and haloperidol injection in the treatment of manic agitation without psychotic symptoms in the acute phase of manic episode was similar,but the safety of the former was higher.

关 键 词：丙戊酸钠注射液 氟哌啶醇注射液 不伴有精神病性症状双相障碍躁狂发作 急性期激越症状 安全性评价 

分 类 号：R971.43[医药卫生—药品]