性激素对骨密度及骨形态影响的研究进展  

Progress in the effects of sex steroids on bone mineral density and morphology

作　　者：张睿[1] 伍学焱[1] Zhang Rui;Wu Xueyan(Laboratory of Endocrinology,Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生部内分泌重点实验室

出　　处：《中华内分泌代谢杂志》2019年第11期986-990,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81771576)。

摘　　要：性激素在骨骼生长发育及维持方面发挥重要作用.年轻成年男性比女性骨强度及骨结构更优,是雄激素充分发挥作用造成的,包括雄激素本身以及转化为雌二醇和双氢睾酮促进骨骼生长.随着年龄增长,男性出现骨量下降较女性更晚,与雌激素水平下降有关.本文将总结成年两性骨骼生长及骨量维持的差异及原因,并以病理模型作为支持,总结性激素对骨密度及骨形态影响的研究进展.Sex steroids play an important role in the growth,development,and maintenance of the bone.Sex differences are observed in bone mass growth.Bone structure and strength in young males are stronger than young females,which are results of the fully utilization of androgen containing testosterone,its aromatization and its reduction products.As male and female growing older,the reduction in bone mass of males happens later than that of females,which are result of the more moderate decrease of estrogen in males.Our review is to summarize the effects of bone metabolism differences between males and females based on several clinical pathological models and to review the latest researches in this field.

关 键 词：性激素 骨密度 骨形态 

分 类 号：R58[医药卫生—内分泌]