补肺化瘀通络汤治疗慢性肺栓塞疗效及对呼吸功能和血氧饱和度水平的影响  

Effect of Bufei Huayu Tongluo Decoction on Respiratory Function and Blood Oxygen Saturation Level in Patients with Chronic Pulmonary Embolism

作　　者：张守军 徐宝清 周芬 ZHANG Shoujun;XU Baoqing;ZHOU Fen(Tangshan Workers*Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市工人医院

出　　处：《中华中医药学刊》2019年第11期2802-2805,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省科技支撑计划项目(20162178)

摘　　要：目的:探究补肺化瘀通络汤治疗慢性肺栓塞疗效及对患者呼吸功能和血氧饱和度影响性。方法:纳入2017年5月-2018年5月医院收治符合纳入条件慢性肺栓塞患者46例,按照就诊顺序编号随机分为对照组(23例)和研究组(23例)。对照组予常规西医治疗,研究组加补肺化瘀通络汤治疗,治疗8周。观察治疗前、完成治疗后在呼吸功能第1秒用力呼气容积(FVE1)、FVE1占预计值、FVE1/FVC(肺活量)、血清高迁移率族蛋白B1(HMGB-1)变化并比较;观察两组治疗前、完成治疗后凝血酶原时间(PT)、纤维蛋白原(FIB)、血小板计数(PLT)变化并比较;观察治疗前、完成治疗后在D二聚体(D-D)、肿瘤坏死因子-α(TNF-α)、血氧饱和度变化并比较;比较完成治疗后后在疗效变化情况。结果:①治疗前两组FVE1、FVE1占预计值、FVE1/FVC、HMGB-1比较差异具有可比性(P>0.05),完成治疗后两组FVE1、FVE1占预计值、FVE1/FVC较治疗前均显著升高,HMGB-1较治疗前显著下降(P<0.05),完成治疗后研究组HMGB-1显著低于对照组,FVE1、FVE1占预计值、FVE1/FVC显著高于对照组(P均<0.05)。②治疗前两组PT、FIB、PLT比较差异具有可比性(P>0.05),完成治疗后两组以上指标较治疗前均显著升高(P<0.05),完成治疗后研究组以上指标均显著高于对照组(均P<0.05)。③治疗前两组D-D、TNF-α、血氧饱和度比较差异具有可比性(P>0.05),完成治疗后两组D-D、TNF-α较治疗前均显著下降,血氧饱和度较治疗前显著升高(P<0.05),完成治疗后研究组D-D、TNF-α显著低于对照组,血氧饱和度显著高于对照组(均P<0.05)。④研究组显效率、总有效率显著高于对照组,比较有统计学意义(P<0.05)。结论:补肺化瘀通络汤能改善慢性肺栓塞患者呼吸功能,提高血氧饱和度,抑制炎症反应,提高凝血酶原时间,从而提高疗效。Objective: To explore the effect of Bufei Huayu Tongluo Decoction on respiratory function and oxygen saturation in patients with chronic pulmonary embolism. Methods: Forty-six patients with chronic pulmonary embolism who met the inclusion criteria were enrolled in Our hospital from May 2017 to May 2018. They were randomly divided into control group(23 cases) and research group(23 cases). The control group was treated with routine western medicine, while the study group was treated with Bufei Huayu Tongluo Decoction for 8 weeks. The changes of forced expiratory volume(FVE1), FVE1 ratio, FVE1/FVC(vital capacity) and serum high mobility group protein B1(HMGB-1) before and after treatment were observed and compared. The prothrombin time(PT), fibrinogen(FIB) and platelet count before and after treatment were observed and compared between the two groups. PLT changes,the changes of D-dimer(D-D), tumor necrosis factor-alpha(TNF-alpha), oxygen saturation and the changes of curative effect after treatment were observed and compared. Results: Before treatment, FVE1, FVE1, FVC and HMGB-1 in the two groups were significantly different(P>0.05). After treatment, FVE1, FVE1 and FVE1/FVC in the two groups were significantly higher than those before treatment and HMGB-1 was significantly lower than that before treatment(P<0.05). After treatment, HMGB-1 in the study group was significantly lower than that in the control group(P<0.05). FVE1 and FVE1 accounted for the predicted value and FVE1/FVC were significantly higher than those of the control group(all P<0.05).(2)There were significant differences in PT, FIB and PLT between the two groups before treatment(P>0.05). After treatment, the above indexes of the two groups were significantly higher than those of the control group(P<0.05). After treatment, the above indexes of the study group were significantly higher than those of the control group(P<0.05).(3) There were significant differences in D-D, TNF-alpha and oxygen saturation between the two groups before treatment(P>0.05). Aft

关 键 词：补肺化瘀通络汤 慢性肺栓塞 呼吸功能 血氧饱和度 凝血功能 炎症指标 疗效 高迁移率族蛋白B1 

分 类 号：R563.5[医药卫生—呼吸系统]