肝素药理作用和药物制剂的研究新进展  

Promising Novel Applications of Heparin

作　　者：张红玉 崔慧斐[1] ZHANG Hong-yu;CUI Hui-fei(School of Pharmaceutical Sciences,National Glycoengineering Research Center,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学药学院国家糖工程技术研究中心

出　　处：《中国药学杂志》2019年第22期1831-1839,共9页Chinese Pharmaceutical Journal

基　　金：山东省科技重大专项(重大关键技术)资助(2015ZDJS04002)

摘　　要：肝素作为一线抗凝剂在临床上已经有着80年的应用。肝素抗凝特性主要是通过与抗凝血酶Ⅲ(antithrombin Ⅲ,ATⅢ)的相互作用来发挥。现已发现与肝素存在相互作用的功能蛋白有百余种,表明肝素有众多非抗凝活性具有研发为新药的潜能,如抗肿瘤、抗炎、抗病毒、抗疟疾、抗贫血。此外,肝素还有望用于载药工具以及功能化植入材料;肝素寡糖还有望通过生物工程、化学/酶法合成途径获取。笔者综述肝素的这些新应用和新进展。Heparin has been used as first-line anticoagulant clinically for 80 years.Heparin mainly exerts its anticoagulant activity through interaction with ATⅢ.It has been found there are more than one hundred heparin-dependent functional proteins which demonstrates promising novel application beyond anticoagulant,such as anti-tumor,anti-malaria anti-inflammation,anti-viral,anti-malaria anti-anemia,etc.Heparin is also hopeful to be used as tool for drug delivery vehicle and functionalized implants material.In addition,heparin oligosaccharides are expected to be produced by chemical/enzymatic and bioengineering synthesis.Above mentioned new developments of heparin are covered in this review.

关 键 词：肝素 非抗凝活性 抗肿瘤 抗炎 抗疟疾 化学/酶法合成 

分 类 号：R973[医药卫生—药品]