8-(N,N-二甲基-胺甲基)-黄芩苷的抗真菌效用研究  

Antifungal effect of 8-(N,N-dimethyl-amine methyl)-baicalin

作　　者：欧阳俊杰[1] OUYANG Jun-jie(Medical College of Yichun University,Yichun,Jiangxi 336000,China)

机构地区：[1]宜春学院医学院外科学教研室

出　　处：《中华医院感染学杂志》2019年第21期3229-3232,共4页Chinese Journal of Nosocomiology

基　　金：江西省卫生计生委科技计划基金资助项目(20163015)

摘　　要：目的初步分析并探讨8-(N,N-二甲基-胺甲基)-黄芩苷的抗真菌效用,为扩展其应用范围进行初步探索。方法选择3种真菌标准菌株和2种真菌临床菌株作为供试菌株,检测8-(N,N-二甲基-胺甲基)-黄芩苷、黄芩苷与伊曲康唑对供试菌株的抑菌圈直径。结果3种药品对供试菌株均有一定的抗真菌效用。8-(N,N-二甲基-胺甲基)-黄芩苷对白假丝酵母、新型隐球菌的标准菌株与临床菌株的抑菌圈直径明显大于黄芩苷,差异有统计学意义(P<0.05)。8-(N,N-二甲基-胺甲基)-黄芩苷对白假丝酵母与新型隐球菌的临床菌株的抑菌圈直径明显大于伊曲康唑,差异有统计学意义(P<0.05)。8-(N,N-二甲基-胺甲基)-黄芩苷对克柔假丝酵母标准菌株的抑菌圈直径明显小于伊曲康唑,差异有统计学意义(P<0.05)。结论8-(N,N-二甲基-胺甲基)-黄芩苷对白假丝酵母、新型隐球菌的标准菌株和临床菌株的抗真菌效用优于黄芩苷;其对白假丝酵母与新型隐球菌的临床菌株的抗真菌效用优于伊曲康唑,对克柔假丝酵母标准菌株的抗真菌效用弱于伊曲康唑。OBJECTIVE To preliminarily analyze and explore the antifungal effect of 8-(N,N-dimethyl-amine methyl)-baicalin so as to expand the application range.METHODS Totally 3 species of standard fungal strains and 2 species of clinical fungal strains were chosen as the tested strains so as to determine the inhibition zone diameters of 8-(N,N-dimethyl-amine methyl)-baicalin,baicalin and itraconazole.RESULTS The 3 types of drugs had certain antifungal effects on the tested strains.The inhibition zone diameters of 8-(N,N-dimethyl-amine methyl)-baicalin were significantly greater than those of baicalin on the standard strains and clinical isolated strains of Candida albican and Cryptococcus neoformans(P<0.05).The inhibition zone diameters of 8-(N,N-dimethyl-amine methyl)-baicalin were significantly greater than those of itraconazole on the clinical isolated strains of C.albican and C.neoformans(P<0.05).The inhibition zone diameter of 8-(N,N-dimethyl-amine methyl)-baicalin was significantly less than that of itraconazole on standard strains of Candida krusei(P<0.05).CONCLUSION The antifungal effect of 8-(N,N-dimethyl-amine methyl)-baicalin is obviously better than that of baicalin on the standard strains and clinical isolated strains of C.albican and C.neoformans;the antifungal effect of 8-(N,N-dimethyl-amine methyl)-baicalin is better than that of itraconazole on the clinical strains of C.albican and C.neoformans;the antifungal effect of 8-(N,N-dimethyl-amine methyl)-baicalin is less than that of itraconazole on the standard strains of C.krusei.

关 键 词：8-(N N-二甲基-胺甲基)-黄芩苷 黄芩苷 伊曲康唑 白假丝酵母 克柔假丝酵母 新型隐球菌 

分 类 号：R379.4[医药卫生—病原生物学]