可溶性糖蛋白130与稳定型冠心病患者冠状动脉粥样硬化严重程度之间关系  

Relationship between soluble glycoprotein 130 and severity of coronary atherosclerosis in patients with stable coronary artery disease

作　　者：张娟娜 林佩环 揭海 ZHANG Juan-na;LIN Pei-huan;JIE Hai(Department of Cardiology,Huizhou Sixth People's Hospital,Huizhou 516200,China)

机构地区：[1]惠州市第六人民医院心内科

出　　处：《中国心血管病研究》2019年第12期1115-1119,共5页Chinese Journal of Cardiovascular Research

基　　金：广东省自然科学基金(B2015152);惠州市临床重点专科项目经费资助(2019Y292)~~

摘　　要：目的探讨稳定型冠状动脉疾病(coronary artery disease,CAD)患者血清可溶性糖蛋白130(sgp130)和白细胞介素-6(IL-6)、可溶性IL-6受体(sIL-6R)浓度及与冠状动脉粥样硬化严重程度间的关系。方法纳入2017年1月至2019年1月间于惠州市第六人民医院心内科具有冠状动脉造影适应证疑似冠心病患者89例,根据冠状动脉造影结果将患者分成两组:存在冠状动脉粥样斑块CAD组,即粥样斑块组,共64例;不存在冠状动脉粥样斑块CAD组,即非粥样斑块组,共25例。采用ELISA法检测两组患者血清IL-6、sIL-6R和sgp 130浓度,Spearman相关分析sgp 130浓度与受累冠状动脉数目及Gensini评分的相关性,多因素Logistic回归分析冠状动脉粥样硬化斑块病变的预测因子。结果粥样斑块组与非粥样斑块组在年龄、BMI、高血压、糖尿病、血脂参数上差异无统计学意义(P>0.05),粥样斑块组患者男性吸烟者居多(P<0.05)。粥样斑块组血清sgp130浓度显著低于非粥样斑块组[(314.97±84.39)ng/ml比(399.08±79.99)ng/ml,P<0.001],粥样斑块组血清IL-6浓度显著高于非粥样斑块组(P<0.05),粥样斑块组血清sIL-6R浓度和C-反应蛋白浓度(CRP)与非粥样斑块组比较差异无统计学意义。多因素Logistic回归分析示,血清sgp130浓度是冠状动脉粥样硬化斑块病变存在的预测因子(P=0.018)。血清sgp130浓度与受累冠状动脉数目间呈负相关(r=-0.310,P=0.007),Gensini评分指数与血清sgp130浓度呈负相关(r=-0.410,P=0.001),稳定型CAD患者sgp130浓度是Gensini评分指数独立危险因素。结论稳定型CAD患者血清sgp130浓度与冠状动脉损伤严重程度呈负相关,血清sgp130水平是冠状动脉粥样硬化严重程度标志物。Objective To investigate the relationship between the concentrations of soluble gp130 protein(sgp130)and interleukin-6(IL-6)and soluble IL-6 receptor(sIL-6 R)in the patients with stable coronary artery disease(CAD)and the severity of coronary atherosclerosis.Methods From January 2017 to January 2019,89 patients with suspected coronary heart disease with angiographic indications were enrolled in the Department of Cardiology,Huizhou Sixth People’s Hospital.According to the results of coronary angiography,the patients were divided into two groups:the CAD group with coronary atherosclerotic plaque(64 cases)and the CAD group without coronary atherosclerotic plaque(25 cases).ELISA method was used to detect plasma IL-6,sIL-6 R and sgp130 concentrations in the two groups’patients.Spearman correlation analysis was used to analyze the correlation between sgp130 concentration and the number of involved coronary arteries and Gensini score.Multivariate Logistic regression was used to analyze the predictors of coronary atherosclerotic plaque lesions.Results There was no significant difference in age,BMI,hypertension,diabetes mellitus and blood lipid parameters between the two group(P>0.05).There were more male smokers in atherosclerotic plaque group(P<0.05).Serum sgp130 concentration in atherosclerotic plaque group was significantly lower than that in nonatherosclerotic plaque group[(314.97±84.39)ng/ml vs.(399.08±79.99)ng/ml,P<0.001].Serum IL-6 concentration in atherosclerotic plaque group was significantly higher than that in non-atherosclerotic plaque group(P<0.05).There was no significant difference in serum sIL-6 R concentration and C-reactive protein concentration(CRP)between the two group.Multivariate Logistic regression analysis showed that serum sgpl30 concentration was a predictor of the presence of coronary atherosclerotic plaque lesions(P=0.018).Serum sgp130 concentration was negatively correlated with the number of coronary arteries involved(r=-0.310,P=0.007).Gensini score index was negatively correlated with

关 键 词：动脉粥样硬化 严重程度 白细胞介素6 可溶性白细胞介素6受体 可溶性糖蛋白130 

分 类 号：R541.4[医药卫生—心血管疾病]