清肺化痰汤联合常规疗法治疗慢性阻塞性肺疾病急性加重期临床研究  

Clinical Study on Qingfei Huatan Tang Combined with Routine Therapy for Acute Exacerbation Chronic Obstructive Pulmonary Disease

作　　者：蒋欢欢 JIANG Huanhuan

机构地区：[1]温州市中西医结合医院呼吸科

出　　处：《新中医》2019年第12期55-58,共4页New Chinese Medicine

摘　　要：目的:观察清肺化痰汤联合常规疗法治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果。方法:纳入本院呼吸内科诊治的104例痰热蕴肺型AECOPD患者作为研究对象,根据随机数字表法分成试验组和常规组各52例,2组均应用常规疗法治疗,试验组同时联用清肺化痰汤治疗,治疗2周后,对比分析2组的临床疗效,并于治疗前后测定2组患者的肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积与用力肺活量的比值(FEV/FVC)]、氧化/抗氧化指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、还原性谷胱甘肽(GSH)]水平。结果:治疗后,试验组总有效率为96.15%,高于常规组的82.69%,差异有统计学意义(P<0.05)。2组FEV1、FVC及FEV/FVC均高于治疗前(P<0.05),试验组3项指标值均高于常规组(P<0.05)。2组SOD、GSH水平均高于治疗前,MDA水平均低于治疗前,差异均有统计学意义(P<0.05),试验组SOD、GSH水平均高于常规组,MDA水平低于常规组,差异均有统计学意义(P<0.05)。结论:清肺化痰汤和常规疗法联用治疗AECOPD能实现良好协同效用,效果理想,能有效缓解症状、改善肺功能,且可有效调节机体氧化/抗氧化失衡,减少急性期氧化产物产生。Objective:To observe the clinical effect of Qingfei Huatan tang combined with routine therapy for patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Enrolled 104 cases of AECOPD patients of phlegm-heat obstructing the lung type in the respiratory department in our hospital as study objects and divided them into the experiment group and the routine group according to the random number table,with 52 cases in each group.Both groups were treated with routine therapy,while the experiment group was additionally given Qingfei Huatan tang.After the treatment for two weeks,compared and analyzed the clinical effect in the two groups and determined the levels of lung function indexes[forced expiratory volume in first second(FEV1),forced vital capacity(FVC),ratio of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC)]and oxidation/antioxidation indexes[superoxide dismutase(SOD),malondialdehyde(MDA),reduced glutathione(GSH)]in the two groups before and after treatment.Results:After treatment,the total effective rate in the experiment group was 96.15%,being higher than that of 82.69%in the routine group,difference being significant(P<0.05).FEV1,FVC and FEV1/FVC in the two groups were higher than those before treatment(P<0.05),and the three indexes in the experiment group were all higher than those in the routine group(P<0.05).The levels of SOD and GSH in both groups were higher than those before treatment,while MDA levels were lower than those before treatment,differences being significant(P<0.05).The levels of SOD and GSH in the experiment group were higher than those in the routine group,while MDA levels were lower than those in the routine group,differences being significant(P<0.05).Conclusion:The application of Qingfei Huatan tang combined with routine therapy for AECOPD patients can achieve good synergistic effects with ideal effect,availably relieve the symptoms and improve lung function.It can aslo effectively regulate the imbalance of oxidation/anti-oxi

关 键 词：慢性阻塞性肺疾病急性加重期 痰热蕴肺型 中西医结合疗法 清肺化痰汤 肺功能 氧化/抗氧化失衡 

分 类 号：R563.9[医药卫生—呼吸系统]