射干麻黄汤联合西药治疗支气管哮喘急性发作随机平行对照研究  

Randomized Parallel Control Study of Shegan Mahuang Decoction Combined with Western Medicine in Treatment of Acute Attack of Bronchial Asthma

作　　者：苏干伸 SU Ganshen(Department of Pulmonary Disease,Guigang Hospital of Traditional Chinese Medicine,Guigang 537100,Guangxi,China)

机构地区：[1]广西贵港市中医医院肺病科

出　　处：《实用中医内科杂志》2019年第10期20-23,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察射干麻黄汤联合西药治疗支气管哮喘急性发作疗效。[方法]使用随机平行对照方法,将98例门诊患者按随机数字表法随机分为两组。对照组49例轻度:氟替卡松,2喷/鼻孔,1次/d;沙丁胺醇,1~2喷/次,间隔时间>4 h,24 h内不超过8次。中度:沙美特罗替卡松粉吸入剂,250~500μg/次,2次/d。治疗组49例射干麻黄汤(射干9 g,麻黄、生姜各12 g,细辛、紫菀、款冬花、半夏各9 g,五味子3 g,大枣7枚,苏子、瓜蒌、杏仁、白前、陈皮各9g),水煎400 m L,1剂/d,2次/d,早晚温服;西药治疗同对照组。连续治疗14 d为1疗程。观测临床表现、哮喘控制测试(ACT)、FEV1%、FVC、昼夜PEF变异率、中医证候积分、不良反应。治疗1疗程(14 d),判定疗效。[结果]治疗组临床控制28例,显效11例,有效7例,无效3例,总有效率93.88%;对照组临床控制20例,显效10例,有效9例,无效10例,总有效率79.59%;治疗组疗效优于对照组(P<0.05)。ACT、FEV1%、FVC、昼夜PEF变异率、中医证候积分两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]射干麻黄汤联合西药治疗支气管哮喘急性发作,疗效满意,无严重不良反应,值得推广。[Objective]To observe the curative effect of Shegan Mahuang Decoction combined with western medicine on acute attack of bronchial asthma.[Method]Ninety-eight outpatients were randomly divided into two groups by random number table method.Forty-nine cases in the control group were mild:fluticasone,2 sprays/nostrils,once a day;salbutamol,1-2 sprays/times,interval time>4 hours,no more than8 times within 24 hours.Medium:Salmeterol roticasone powder inhalation,250-500μg/time,twice a day.In the treatment group,49 patients were treated with Shegan Mahuang Decoction,decocted with water400 m L,1 dose/d,twice a day,taking in the morning and evening.The Western medicine was the same as that of the control group.Continuous treatment for 14 days was a course of treatment.The clinical manifestations,asthma control test(ACT),FEV1%,FVC,day and night PEF variation rate,TCM syndrome score and adverse reactions were observed.One course of treatment(14 days)was used to determine the curative effect.[Result]In the treatment group,28 cases were clinically controlled,11 cases were markedly effective,7 cases were effective,3 cases were ineffective,and the total effective rate was 93.88%.In the control group,20 cases were clinically controlled,10 cases were markedly effective,9 cases were effective and10 cases were ineffective,and the total effective rate was 79.59%.The curative effect of the treatment group was better than that of the control group(P<0.05).ACT,FEV1%,FVC,variation rate of day and night PEF and integral of TCM syndromes were improved in both groups(P<0.05,P<0.01).The improvement of treatment group was better than that of control group(P<0.05,P<0.01).[Conclusion]Shegan Mahuang Decoction combined with western medicine in the treatment of acute attack of bronchial asthma has satisfactory curative effect and no serious adverse reactions,which is worthy of promotion.

关 键 词：哮喘 急性发作期 哮病 射干麻黄汤 哮喘控制测试 FEV1% FVC 昼夜PEF变异率 中医证候积分 中药复方 随机平行对照研究 

分 类 号：R28[医药卫生—中药学]