复方丹参注射液联合硫酸镁对早发型重度子痫前期患者TLR4的影响及机制探讨  

Effect and mechanism of compound salvia miltiorrhiza injection combined with magnesium sulfate on TLR4 level of women with early onset severe preeclampsia

作　　者：卜春艳 王颖 王微 范永周 郭战坤[1] 王志芳[1] BU Chunyan;WANG Ying;WANG Wei;FAN Yongzhou;GUO Zhankun(Baoding Maternal and Child Health Care Hospital,Hebei Province,071000)

机构地区：[1]河北省保定市妇幼保健院

出　　处：《中国计划生育学杂志》2019年第12期1667-1670,共4页Chinese Journal of Family Planning

基　　金：河北省保定市社发类项目(18ZF062)

摘　　要：目的:探讨复方丹参注射液联合硫酸镁治疗早发型重度子痫前期(EOSPE)患者对Toll样受体4 (TLR4)水平及血管内皮功能和免疫炎性因子的影响及相关机制。方法:选择2016年9月-2019年1月本院收治的EOSPE孕妇118例,采用随机数字法分为观察组59例和对照组59例,对照组硫酸镁治疗,观察组硫酸镁联合复方丹参注射液治疗,共治疗2周。探讨治疗前后两组血清TLR4、血管细胞粘附分子-1(VCAM-1)、内皮素-1(ET-1)、一氧化氮(NO)等及转化生长因子-β1(TGF-β1)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)等水平。结果:治疗后,与治疗前比较观察组与对照组TLR 4水平(3.14±0.89μg/L、3.86±1.05μg/L)、VCAM-1和ET-1水平、TNF-α和IL-6水平均降低,而NO水平和TGF-β1水平均升高,且观察组各指标改善程度优于对照组(P<0.05)。结论:复方丹参注射液联合硫酸镁能显著改善早发型重度子痫前期患者的血管内皮功能和机体免疫炎症状态,同时下调TLR 4表达。Objective:To investigate the effects and related mechanism of compound salvia miltiorrhiza injection combined with magnesium sulfate on Toll-like receptor 4(TLR4)level,vascular endothelial function,and immune factors of women with early onset severe preeclampsia(EOSPE).Methods:118 pregnant women diagnosed as EOSPE were selected from September 2016 to January 2019 and were divided in the study group and the control group(59 cases in each group)by random number method.On the basis of routine treatment,the women in the control group were treated with magnesium sulfate,and the women in the study group were treated with magnesium sulfate combined with compound prescription salvia miltiorrhiza injection for 2 weeks.The levels of serum TLR4,vascular cell adhesion molecule-1(VCAM-1),endothelin-1(ET-1),nitric oxide(NO),transforming growth factor-beta 1(TGF-beta 1),tumor necrosis factor(TNF),interleukin-6(IL-6)and other immune cytokines of all women in two groups were detected before and after treatment.Results:The level of TLR-4 of women in the study group and the control group were 3.14±0.89 g/L and 3.86±1.05 g/L,which all had decreased after treatment,and the levels of VCAM-1 and ET-1,TNF and IL-6 had also decreased significantly,while the levels of NO and TGF-beta 1 had significantly increased.Conclusion:Compound salvia miltiorrhiza injection combined with magnesium sulfate can significantly improve vascular endothelial function and immune inflammation of women with early onset severe preeclampsia,and can also down-regulate the expression of TLR-4 of women.

关 键 词：早发型重度子痫前期 复方丹参注射液 硫酸镁 TOLL样受体4 

分 类 号：R71[医药卫生—妇产科学]