氧化石墨烯功能化磁性空心球的制备及载药性能  

Preparation and Drug Delivery of Graphene Oxide Decorated Hollow Magnetic Nanoparticles

作　　者：殷红霞 杨宇翔[1,2] 黄艳 赵怡 倪超英 YIN Hongxia;YANG Yuxiang;HUANG Yan;ZHAO Yi;NI Chaoying(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;Department of Materials Science and Engineering,University of Delaware,DE 19716,USA)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237 [2]特拉华大学材料科学与工程系,美国特拉华州19716

出　　处：《华东理工大学学报（自然科学版）》2019年第6期873-882,共10页Journal of East China University of Science and Technology

基　　金：国家自然科学基金项目（20577010,20971043）

摘　　要：以纳米碳球和十六烷基三甲基溴化铵(CTAB)为双模板合成了具有介孔核-壳结构的纳米复合材料;并通过刻蚀法,制备了磁性介孔纳米空心球(HMNPs);在交联剂1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)和N-羟基硫代琥珀酰亚胺(NHS)的作用下,制备了氧化石墨烯(GO)功能化的磁性介孔纳米空心球(HMNPs-GO)。利用红外光谱(FT-IR)、X-射线粉末衍射(XRD)、拉曼光谱(Raman)、扫描电镜(SEM)、透射电镜(TEM)和振动样品磁强计(VSM)等方法进行了表征。通过研究HMNPs-GO对藤黄酸(GA)的吸附等温线,得出HMNPs-GO对GA的吸附主要为两者之间的π-π堆积,且属于Freundlich吸附。同时,基于Bhaskar模型和准一级、准二级动力学模型,分别探讨了HMNPs-GO中GA药物分子的扩散机理和缓释动力学,得出GA在HMNPs-GO中的缓释具有pH依赖性,且在不同pH下的缓释更适合于准二级动力学模型。A mesoporous shell structure was synthesized using carbon spheres and cetyltrimethylammonium bromide(CTAB) as dual templates, and hollow magnetic nanoparticles(HMNPs) were subsequently prepared by etching. Hollow magnetic nanoparticles functionalized by graphene oxide(HMNPs-GO) were synthesized via the functionalization of HMNPs with NH2 groups and the activation of carboxyl groups of graphene oxide by N-ethyl-NO-(3-(dimethylamino)propyl) carbodiimide/N-hydroxysuccinimide(EDC/NHS). HMNPs and HMNPs-GO were characterized by Fourier transform infrared(FT-IR) spectroscopy, X-ray diffraction(XRD), Raman, scanning electron microscopy(SEM), transmission electron microscopy(TEM) and vibrating sample magnetometer(VSM). Upon the investigations on the adsorption isotherm of HMNPs-GO, it was found that the adsorption of GA by HMNPs-GO was mainly attributed to the π-π accumulation between each other and was refer to Freundlich adsorption. The diffusion mechanism and release kinetics of GA in HMNPs-GO were studied based on Bhaskar model, quasi-first-order, and quasi-second-order kinetic model, respectively. The release of GA showed pH dependence in HMNPs-GO, and the sustained release at different pH followed the quasi-second-order dynamics model.

关 键 词：磁性空心球 氧化石墨烯 药物缓释 

分 类 号：O614.81[理学—无机化学]