莱菔硫烷对糖尿病及脂肪肝病的调控作用研究进展  

Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease

作　　者：孙瑶 张英春 田思聪 李宝龙 单毓娟 SUN Yao;ZHANG Ying-chun;TIAN Si-cong;LI Bao-long;SHAN Yu-juan(Department of Food Science and Engineering,School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin 150001,China;Drug Safety Evaluation Center,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]哈尔滨工业大学化工与化学学院食品科学与工程系,黑龙江哈尔滨150001 [2]黑龙江中医药大学药物安全性评价中心,黑龙江哈尔滨150040

出　　处：《中国药理学与毒理学杂志》2019年第8期628-632,共5页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金（81573135）~~

摘　　要：莱菔硫烷干预能够降低糖尿病患病风险,主要是通过调控核因子E2相关因子2抑制内皮细胞活化,改善高密度脂蛋白水平来实现。此外,莱菔硫烷通过调控脂质代谢,对脂肪肝病也具有明显的改善作用,其重要途径包括调节氧化物酶体增殖剂激活受体γ、激素敏感性脂肪酶和腺嘌呤核糖核苷酸依赖的蛋白激酶,促进脂肪分解。综上,深入挖掘植物性食源功能成分莱菔硫烷的作用机制,可能是防治糖尿病及脂肪肝病的关键。The intervention of sulforaphane can reduce the risk of diabetes and its complications.It is mainly achieved by regulating nuclear factor erythroid-2-related factor 2(Nrf2)to inhibit endothelial cell activation and improve high density lipoprotein levels.In addition,sulforaphane can bring about a marked improvement on fatty liver disease by regulating lipid metabolism.Its important pathways include the regulation of peroxisome proliferators-activated receptorsγ(PPARγ),hormone-sensitive triglyceride lipase(HSL)and AMP-activated protein kinase(AMPK)regulation promotes lipolysis.In summary,further exploration of the mechanism of action of plant-derived functional ingredients of sulforaphane may be the key to preventing and treating diabetes and fatty liver disease.

关 键 词：莱菔硫烷 植物化学物 糖尿病 脂肪肝病 

分 类 号：R97[医药卫生—药品]