喜炎平注射液联合注射用多索茶碱治疗慢性阻塞性肺疾病的临床疗效观察  

Clinical curative effect of Xiyanping injection combined with doxofylline for injection on chronic obstructive pulmonary disease

作　　者：曹敏 杨彩云[1] 龚光辉 Cao Min;Yang Caiyun;Gong Guanghui(First Internal Medicine,Hongdu Chinese Medicine Hospital,Nanchang,Jiangxi,330000,China)

机构地区：[1]南昌市洪都中医院内一科

出　　处：《当代医学》2020年第1期19-21,共3页Contemporary Medicine

摘　　要：目的探讨喜炎平注射液联合注射用多索茶碱治疗慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)的临床疗效。方法选取2015年11月至2018年11月本院收治的60例COPD患者,采用随机数字法分为对照组(多索茶碱治疗)与观察组(在对照组的基础上联合喜炎平治疗),各30例。统计两组临床疗效,比较两组患者在治疗前后的肺活量(vital capacity,VC)、深吸气量(inspiratory capacity,IC)和呼气流量峰值(peak expiratory flow,PEF)以及血清中白细胞介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)和中性粒细胞弹性蛋白酶(neutrophil elastase,NE)的表达水平。结果观察组的治疗有效率为93.33%高于对照组(P<0.05);经过治疗后,观察组的VC、IC和PEF水平高于对照组(P<0.05),观察组的IL-8、TNF-α和NE表达水平低于对照组(P<0.05)。结论喜炎平注射液联合注射用多索茶碱治疗COPD疗效确切,改善肺功能和炎性因子水平。Objective To explore clinical curative effect of Xiyanping injection combined with doxofylline for injection on chronic obstructive pulmonary disease(COPD). Methods 60 cases of COPD patients who were admitted to the hospital from November 2015 to November 2018 were enrolled, they were randomLy divided into control group(doxofylline) and observation group(doxofylline combined with Xiyanping) by random number table method, with 30 cases in each group. The clinical curative effect in both groups was statistically analyzed. The vital capacity(VC), inspiratory capacity(IC), peak expiratory flow(PEF), expression levels of serum interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) and neutrophil elastase(NE) before and after treatment were compared between the two groups. Results The response rate of treatment in observation group(93.33%) was higher than that in control group(P<0.05). After treatment, levels of VC, IC and PEF in observation group were higher than those in control group(P<0.05). The expression levels of IL-8, TNF-α and NE in observation group were lower than those in control group(P<0.05).Conclusion The curative effect of Xiyanping injection combined with doxofylline for injection is significant on COPD, which can improve pulmonary function and inflammatory factors levels.

关 键 词：慢性阻塞性肺疾病 喜炎平 多索茶碱 

分 类 号：R56[医药卫生—呼吸系统]