Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Phlebovirus in Domesticated Deer in South Korea  

作　　者：Min-Ah Yu Kwang-Min Yu Su-Jin Park Young-ll Kim Norbert John Robles Young-Jae Si Eun-Ha Kim Hyeok-ll Kwon Hye Won Jeong Min-Suk Song Seok-Yong Kim Young Ki Choi 

机构地区：[1]Department of Microbiology,College of Medicine and Medical Research Institute,Chungbuk National University,Cheongju 28644,Republic of Korea [2]Zoonotic Infectious Diseases Research Center,Chungbuk National University,Cheongju 28644,Republic of Korea [3]Department of Internal Medicine,College of Medicine and Medical Research Institute,Cheongju 28644,Republic of Korea [4]Department of Internal Medicine,Chungbuk National University Hospital,Cheongju 28644,Republic of Korea

出　　处：《Virologica Sinica》2019年第5期501-507,共7页中国病毒学（英文版）

基　　金：supported by the Ministry of Health & Welfare (government—wide R&D fund project for infectious disease research (HG18C0029)

摘　　要：Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV)has a wide host range.Not only has it been found in humans,but also in many wild and domesticated animals.The infection of breeding deer on farms is a particularly worrisome public health concern due to the large amount of human contact and the diverse use of deer products,including raw blood.To investigate the prevalence of breeding domesticated deer,we examined the SFTSV infection rate on deer farms in South Korea from 2015 to 2017.Of the 215 collected blood samples,0.9%(2/215)were found to be positive for viral RNA by PCR,and sequence analysis showed the highest homology with the KADGH human isolate.Both SFTSVspecific recombinant N and Gn protein-based ELIS As revealed that 14.0%(30/215)and 7.9%(17/215)of collected blood specimens were positive for SFTSV antibody.These results demonstrate that the breeding farm deer are exposed to SFTSV and could be a potential infection source for humans through direct contact or consumption of byproducts.Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV) has a wide host range. Not only has it been found in humans, but also in many wild and domesticated animals. The infection of breeding deer on farms is a particularly worrisome public health concern due to the large amount of human contact and the diverse use of deer products, including raw blood. To investigate the prevalence of breeding domesticated deer, we examined the SFTSV infection rate on deer farms in South Korea from 2015 to 2017. Of the 215 collected blood samples, 0.9%(2/215) were found to be positive for viral RNA by PCR, and sequence analysis showed the highest homology with the KADGH human isolate. Both SFTSVspecific recombinant N and Gn protein-based ELISAs revealed that 14.0%(30/215) and 7.9%(17/215) of collected blood specimens were positive for SFTSV antibody. These results demonstrate that the breeding farm deer are exposed to SFTSV and could be a potential infection source for humans through direct contact or consumption of byproducts.

关 键 词：Severe fever with thrombocytopenia syndrome phlebovirus(SFTSV) Breeding deer•Seroprevalence South Korea 

分 类 号：R51[医药卫生—内科学]