高血压心衰合并高尿酸血症患者hURAT1(T6092C)基因多态性对氯沙坦降尿酸疗效的影响  

Effect of hURAT1(T6092C) Gene Polymorphism on the Efficacy of Losartan in Reducing Uric Acid in Patients with Hypertensive Heart Failure Complicated with Hyperuricemia

作　　者：余广炜[1] 刘青[1] 吴文伟[1] YU Guang-wei;LIU Qing;WU Wen-wei(Department of Emergency,Union Hospital,Fujian Medical University,Fuzhou,Fujian Province,350000 China)

机构地区：[1]福建医科大学附属协和医院急诊科

出　　处：《中外医疗》2019年第32期4-6,9,共4页China & Foreign Medical Treatment

摘　　要：目的探讨hURAT1(T6092C)基因多态性对高血压心衰合并高尿酸血症患者服用氯沙坦疗效的影响。方法方便选取2014年1月—2018年8月该院急诊科收治的高血压性心脏病、心功能不全合并高尿酸血症患者146例为研究对象,应用多聚酶链-限制性片段长度多态性(PCR-RFLP)方法检测146例患者的hURAT1(T6092C)基因多态性,同时观察不同基因组服用氯沙坦后尿酸值下降幅度的差异。结果患者TT、TC、CC 3组基因型服用氯沙坦后尿酸值下降幅度差异有统计学意义(P<0.05),TT基因型个体血尿酸下降幅度为(132.3±62.7)μmol/L,高于TC(7.3±12.4)μmol/L和CC基因型个体(2.0±13.9)μmol/L。结论氯沙坦对hURAT1(T6092C)基因突变的高血压性心脏病、心功能不全合并高尿酸血症患者疗效降低,应该注意联合用药提高疗效。Objective To investigate the effect of hURAT1(T6092C)gene polymorphism on the efficacy of losartan in patients with hypertensive heart failure complicated with hyperuricemia.Methods Convenient selected a total of 146 patients with hypertensive heart disease,cardiac insufficiency and hyperuricemia admitted to the hospital from January 2014 to August 2018 were enrolled in the study.Polymerase-restriction fragment length polymorphism was used.The(PCR-RFLP)method was used to detect the hURAT1(T6092C)gene polymorphism in 146 patients,and to observe the difference in the decrease in uric acid value after taking losartan in different genomes.Results There was a statistically significant difference in the decrease of uric acid value between patients with TT,TC and CC genotypes after taking losartan(P<0.05),the decrease of blood uric acid in TT genotype was(132.3±62.7)μmol/L,higher than TC(7.3±12.4)μmol/L and CC genotype(2.0±13.9)μmol/L.Conclusion Losartan is effective in the treatment of hypertensive heart disease,cardiac insufficiency and hyperuricemia with hURAT1(T6092C)gene mutation.It should be noted that the combination therapy can improve the curative effect.

关 键 词：hURAT1 氯沙坦 疗效 高血压 高尿酸血症 基因多态性 

分 类 号：R589[医药卫生—内分泌]