Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective  

作　　者：LUO Ting-ting LU Yuan YAN Shi-kai XIAO Xue RONG Xiang-lu GUO Jiao 

机构地区：[1]Institute of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China [2]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine,Guangzhou 510006,China [3]School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Chinese Journal of Integrative Medicine》2020年第1期72-80,共9页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81530102);Guangdong Provincial Science and Technology Agency Special Funds(No.2017B050504005);Guangzhou City Science and Technology Agency Special Funds(No.201803010069)

摘　　要：Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.Chinese medicine(CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.

关 键 词：network pharmacology Chinese medicine formula targets discovery mechanism research quality control research 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]