四逆散干预焦虑症作用机制的网络药理学分析  

Internet pharmacology analysis of mechanism of Sini Powder in intervening anxiety disorder

作　　者：侯磊 李晓宇[2] 黄娜娜 吴成胜 齐晓甜 刘闰平 孙蓉 HOU Lei;LI Xiao-yu;HUANG Na-na;WU Cheng-sheng;QI Xiao-tian;LIU Run-ping;SUN Rong(The Second Hospital of Shandong University,Jinan 250033,China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Institute of Advanced Medical Sciences,Shandong University,Jinan 250012,China;Affiliated Hospital of Taishan Medical University,Taian 271000,China;Beijing University of Traditional Chinese Medicine,Beijing 100029,China)

机构地区：[1]山东大学第二医院,山东济南250033 [2]山东中医药大学,山东济南250355 [3]泰山医学院附属医院,山东济南250012 [4]山东大学高等医学研究院,山东泰安271000 [5]北京中医药大学,北京100029

出　　处：《中草药》2019年第21期5154-5161,共8页Chinese Traditional and Herbal Drugs

基　　金：山东省重点研发计划(重大关键技术)项目(2016ZDJS07A21);山东省重点研发计划项目(2017CXGC1301);山东省重点研发计划项目(2016GSF202039);国家自然科学基金面上项目(81773997);泰山学者工程专项经费资助(ts201511107)

摘　　要：目的探讨四逆散干预焦虑症的功效作用网络及药效作用机制。方法运用网络药理学方法,多个数据库联合分析四逆散和焦虑症的作用靶点,通过Cytoscape筛选靶点并对其基因功能和信号通路进行分析,运用Bio GPS数据库对所得靶点进行器官定位。结果分析结果表明槲皮素、山柰酚、芍药苷等成分作用于SRC、EGFR、PIK3R1等靶点,通过ERBB2信号通路、EGFRv III信号通路、VEGFA-VEGFR2信号通路等共同发挥作用,器官定位结果表明作用的核心病位为肝。结论四逆散干预焦虑症体现了中药多成分、多靶点、多通路的作用特点。Objective To explore the efficacy network and pharmacodynamic mechanism of Sini Powder in the intervention of anxiety disorders.Methods Using the method of network pharmacology,multiple databases were used to analyze the targets of Sini Powder and anxiety disorders.Cytoscape was used to screen targets and analyze their gene functions and signaling pathways.BioGPS database was used to locate the target organs.Results The results showed that quercetin,kaempferol,and paeoniflorin acted on SRC,EGFR,PIK3 R1,and other targets,through ERBB2 signaling pathway,EGFRv III signaling pathway,and VEGFA-VEGFR2 signaling pathway.The results of organ localization showed that the core disease site was liver.Conclusion By predicting the possible mechanism of Sini Powder in the intervention of anxiety disorder,this study reflects the characteristics of Chinese medicine in the multi-component,multi-target,and multi-channel role,which provides a scientific basis for further elucidating the mechanism of Sini Powder in the intervention of anxiety disorder.

关 键 词：四逆散 焦虑症 网络药理学 槲皮素 山柰酚 芍药苷 

分 类 号：R285.5[医药卫生—中药学]