离舌橐吾的化学成分研究  

Study on chemical constituents of Ligularia veitchiana

作　　者：赵倩倩 王静 王旭阳 曹云刚 ZHAO Qian-qian;WANG Jing;WANG Xu-yang;CAO Yun-gang(College of Food and Biological Engineering,Shaanxi University of Science and Technology,Xi’an 710000,China)

机构地区：[1]陕西科技大学食品与生物工程学院

出　　处：《中草药》2019年第21期5212-5216,共5页Chinese Traditional and Herbal Drugs

基　　金：陕西省科技厅基金资助项目(2019JQ-252);陕西省科技厅基金资助项目(2019JQ-453);国家自然科学基金青年基金项目(31801480)

摘　　要：目的对离舌橐吾Ligularia veitchiana地上部分的化学成分进行研究。方法利用大孔吸附树脂、硅胶柱色谱、半制备高效液相色谱、葡聚糖凝胶等多种色谱方法分离纯化,根据理化性质及波谱数据对化合物进行结构鉴定。结果从离舌橐吾95%乙醇提取物中分离得到16个化合物,分别鉴定为2-hydroxplatyphyllide(1)、ligudentatin A(2)、2-metyoxy-platyphillide(3)、7-hydroxy-11-hydroperoxybisabol-2,9E-diene(4)、bisabola-2,11-diene-7α,10ζ-diol(5)、8β,10β-dihydroxyeremophilenolide(6)、3β(ax)-hydroxyeremophillenolide(7)、6β-hydroxy-8α-ethoxyeremophil-7(11)-en-12,8β-olide(8)、3β,28-dibydroxylup-20(29)-ene(9)、齐墩果酸(10)、3β-hydroxyolean-12-en-27-oic acid(11)、乌苏酸(12)、阿魏酸松柏酯(13)、4-O-geranyl-sinapyl alcohol(14)、4-O-geranyl-coniferyl alcohol(15)、橙皮油素(16)。结论所有化合物均为首次从该植物中分离得到,其中化合物4、5、7、8、11为首次从橐吾属植物中分离得到。Objective To study the chemical constituents of the aerial parts of Ligularia veitchiana.Methods The isolation and purification were carried out by macroporous resin,silica gel column chromatography,Sephadex LH-20,and semi-preparative HPLC.Their structures were elucidated on the basis of physicochemical properties and spectroscopic data.Results A total of 16 compounds were isolated and elucidated from the aerial parts of Ligularia veitchiana,their structures were identified as:2-hydroxplatyphyllide(1),ligudentatin A(2),2-metyoxy-platyphillide(3),7-hydroxy-11-hydroperoxybisabol-2,9 E-diene(4),bisabola-2,11-diene-7α,10ζ-diol(5),8β,10β-dihydroxyeremophilenolide(6),3β(ax)-hydroxyeremophillenolide(7),6β-hydroxy-8α-ethoxyeremophil-7(11)-en-12,8β-olide(8),3β,28-dibydroxylup-20(29)-ene(9),oleanolic acid(10),3β-hydroxyolean-12-en-27-oic acid(11),ursolic acid(12),coniferyl ferulate(13),4-O-Geranyl-sinapyl alcohol(14),4-O-geranyl-coniferyl alcohol(15),auraptene(16).Conclusion All compounds are isolated from Ligularia veitchiana for the first time.Compounds 4,5,7,8,11 are isolated from the genus Ligularia for the first time.

关 键 词：离舌橐吾 倍半萜 芥子醇 7-hydroxy-11-hydroperoxybisabol-2 9E-diene 3β(ax)-hydroxyeremophillenolide 乌苏酸 阿魏酸松柏酯 

分 类 号：R284.1[医药卫生—中药学]