小花鬼针草中1个新的橙酮苷类化合物  

A new aurone glycoside from Bidens parviflora

作　　者：李传厚 朱彦军 于绍华 蒋海强[1] 周洪雷[1] LI Chuan-hou;ZHU Yan-jun;YU Shao-hua;JIANG Hai-qiang;ZHOU Hong-lei(School of Pharmaceutical Sciences Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Medical College,Linyi 276000,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东医学高等专科学校,山东临沂276000

出　　处：《中草药》2019年第22期5389-5394,共6页Chinese Traditional and Herbal Drugs

基　　金：山东省中医药科技发展计划(2019-0315);山东省重点研发计划项目(2017GSF19105)

摘　　要：目的对小花鬼针草Bidens parviflora全草的化学成分进行系统研究。方法对小花鬼针草80%乙醇提取物的醋酸乙酯部位采用硅胶、聚酰胺、Sephadex LH-20及HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从小花鬼针草80%乙醇提取物中分离得到10个化合物,分别鉴定为(Z)-6-O-(4″-O-乙酰基-6″-O-p-香豆酰基-β-D-吡喃葡萄糖基)-6,7,3′,4′-四羟基橙酮(1)、奥卡宁-4′-O-β-D-(6″-乙酰基)-葡萄糖苷(2)、7,3′,4′-三羟基-6-O-(4″,6″-二乙酰基-β-D-吡喃葡萄糖基)-橙酮(3)、6,7,3′,4′-四羟基橙酮(4)、异奥卡宁(5)、丁香酸-4-O-α-L-鼠李吡喃糖苷(6)、奥卡宁-4′-O-β-D-(6″-反式-对-香豆酰基)-吡喃葡萄糖苷(7)、奥卡宁-4′-O-β-D-(4″-乙酰基-6″-反式-对-香豆酰基)-吡喃葡萄糖苷(8)、槲皮素-3,4′-二甲醚-7-O-芸香糖苷(9)、cordifolioidyne B(10)。结论化合物1为1个新化合物,命名为鬼针草苷I,化合物6和10为首次从该属植物中分离得到,其他化合物为首次从该植物中分离得到。Objective To study the chemical constituents of Bidens parviflora.Methods The ethyl acetate fraction of 80%ethanol extract from B.parviflora was isolated and purified by silica,polyamide,Sephadex LH-20,and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Results Ten compounds were isolated and identified as Z-6-O-(4″-O-acetyl-6″-O-p-coumaroyl-β-D-glucopyranosyl)-6,7,3′,4′-tetrahydroxyaurone(1),okanin-4′-O-β-D-(6″-Oacetyl)-glucoside(2),Z-6-O-(4″,6″-diacetyl-β-D-)-7,3′,4′-tetrahydroxy aurone(3),6,7,3′,4′-tetrahydroxy aurone(4),isookanin(5),syringic acid-4-O-α-L-rhamnopyranoside(6),okanin-4′-O-β-D-(6″-trans-p-coumaroyl)-glucoside(7),okanin-4′-O-β-D-(4″-acetyl-6″-trans-p-coumaroyl)-glucoside(8),quercetin-3,4′-dimethyl ether-7-O-rutinoside(9),and cordifolioidyne B(10).Conclusion Compound 1 is a new compound named as bidenoside I,compounds 6 and 10 are isolated from the genus Bidens for the first time,other compounds are isolated from this plant for the first time.

关 键 词：小花鬼针草 Z-6-O-(4″-O-乙酰基-6″-O-p-香豆酰基-β-D-吡喃葡萄糖基)-6 7 3′ 4′-四羟基橙酮 异奥卡宁 丁香酸-4-O-α-L-鼠李吡喃糖苷 槲皮素-3 4′-二甲醚-7-O-芸香糖苷 鬼针草苷I 

分 类 号：R284.1[医药卫生—中药学]