中医药防治腹膜间皮细胞发生上皮细胞-间质转化的研究进展  

Research Progress on Prevention and Treatment of Peritoneal Mesothelial Cells EMT by Traditional Chinese Medicine

作　　者：高新 乔冬雪 王孟孟 李洁[1] 杨波[1] 杨洪涛[1] GAO Xin;QIAO Dongxue;WANG Mengmeng;LI Jie;YANG Bo;YANG Hongtao(The First Affliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China)

机构地区：[1]天津中医药大学第一附属医院

出　　处：《辽宁中医杂志》2019年第11期2457-2460,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81774065);国家青年自然科学基金项目(81303092,81603440);天津市高等学校科技发展基金计划项目(20130215)

摘　　要：腹膜间皮细胞(peritoneal mesothelial cells,PMCs)是人腹膜重要的组成部分,腹膜透析(peritoneal dialysis,PD)期间,高浓度葡萄糖腹膜透析液刺激PMCs分泌促纤维化因子增加,激活TGF-β/Smad等信号通路,使PMCs发生上皮细胞-间质转化(epithelial-mesenchymal transition,EMT),诱发腹膜纤维化,最终导致超滤衰竭,极大的影响了PD患者透析疗效及生活质量。近年研究发现,部分单味中药及部分复方中药可以通过下调促纤维化因子表达,上调抗纤维化因子表达等作用有效的防治EMT的发生和进展,基于此,文章从目前中医药防治EMT的研究进展概况出发,分析论述中医药防治EMT的机制,以期为相关研究的开展提供参考。Peritoneal mesothelial cells are important part of the human peritoneum.During peritoneal dialysi,high concentration glucose peritoneal dialysate can increase the secretion of pro-fibrotic factors by PMCs and activate the signaling pathways such as TGF-β/Smad,leading to epithelial-mesenchymal transition in PMCs,causing peritoneal fibrosis,and ultimately leading to ultrafiltration failure,greatly affecting the dialysis efficacy and quality of life of PD patients.Recent studies have found thatsome single traditional Chinese medicine and some compound Chinese medicine can downgrade the expressions of pro-fibrotic factors and at the same time up-regulate the expressions of anti-fibrotic factors so as to prevent and treat EMT effectively.Based on the above and the current studies progress of traditional Chinese medicine prevention and treatment of EMT,this article analyzed and discussed the mechanism of traditional Chinese medicine prevention and treatment of EMT,hoping to provide reference for the development of related research.

关 键 词：中医药 腹膜透析 腹膜间皮细胞 上皮细胞-间质转化 

分 类 号：R459.5[医药卫生—治疗学]