轻断食与低能量均衡饮食对减重效果及代谢的影响比较  

Comparison of intermittent fasting diet and continuous energy-restricted diet on weight loss and metabolic profile in overweight people

作　　者：房玲玲[1] 李小燕 徐斌斌[4] 邱侠 晋梦诗 金科美 Fang Lingling;Li Xiaoyan;Xu Binbin;Qiu Xia;Jin Mengshi;Jin Kemei(Department of Endocrinology,Ningbo Medical Center Lihuili Hospital,Ningbo 315040,Zhejiang,China;不详)

机构地区：[1]宁波市医疗中心李惠利医院内分泌科,315040 [2]宁波市医疗中心李惠利医院病案统计室,315040 [3]宁波市医疗中心李惠利医院营养科,315040 [4]浙江宁波市第二医院营养科,315010

出　　处：《中华临床营养杂志》2019年第5期309-314,共6页Chinese Journal of Clinical Nutrition

基　　金：浙江省医药卫生研发培育项目(2017PY026);宁波市自然科学基金项目(2017A610266)。

摘　　要：目的比较轻断食与低能量均衡饮食对减重效果及代谢的影响,探讨更适合中国人的减重方法。方法选取超重、肥胖患者60例,每组30例,一组进行低能量减重,一组进行轻断食减重。观察两组减重8周身高、体重、腰围、体重指数(BMI)、体脂肪、内脏脂肪面积改变、空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、高密度胆固醇(HDL)、低密度胆固醇(LDL)、谷氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、空腹胰岛素水平(FINS)、胰岛素抵抗指数(H0 MA-IR)的变化。结果低能量减重及轻断食减重均能在8周有效改善身体形态指标,减轻体重、腰围、BMI、体脂肪、内脏脂肪面积(P<0.01),同时骨骼肌也均下降(P<0.0l)。代谢指标上,低能量组减重8周后TC、AST、ALT、GGT、ALP、FINS、H0 MA-IRB月显下降(P<0.01或P<0.05)。轻断食组减重8周后TC、LDL、HDL、AST、ALT、GGT、ALP、FINS、HOMA-IR指数明显下降(P<0.01或P<0.05)。两组比较,轻断食减重组中HDL明显下降(P<0.01)。结论本研究显示低能量减重及轻断食减重均能有效减轻体重,减重幅度相当,对血糖、胰岛素抵抗、血脂等代谢指标改善也基本相当,但轻断食减重HDL明显下降。Objective To compare the weight loss and metabolic profile between a continuous energyrestricted diet and intermittent fasting diet in order to present an optimal nutritional weight reduction method for obese people in China.Methods Sixty overweight or obese adults were selected and divided into two groups as the continuous energy-restricted diet group and the intermittent fasting diet group.Height,weight,waist circumference,body mass index(BMI),body fat,change of visceral fatarea,fasting glucose(FPG),triglyceride(T G),total cholesterol(TC),high density cholesterol(HDL),low density cholesterol(LDL),glutamic pyruvicaminotransferase(AST),signglutamic pyruvic transaminase(ALT),gammaglutamyltranspeptidase(GGT),alkalinephosphatase(ALP),fasting insulin level(FINS)and HOMA-IR were assessed at baseline and 8 weeks after weight loss methods carried.Results Both continuous energy-restricted diet and intermittent fasting diet resulted improvement on body shape indexes and a significant decrease in weight,waist circumference,BMI,body fat,visceral fat area and skeletal muscle(P<0.01)at 8 weeks.Both groups experienced improvements in biochemical outcomes and metabolic indicators at 8 weeks.A significant reduction in TC,AST,ALT,GGT,ALP,FINS and HOMA-IR(P<0.01 or P<0.05)were observed in continuous energy-restricted diet group.And a significant decline in TC,LDL,HDL,AST,ALT,GGT,ALP,FINS and HOMA-IR were observed in intermittent fasting diet group(P<0.01 or P<0.05).HDL was found significantly reduced in intermittent fasting diet group as compared with continuous energy-restricted diet group(P<0.01)at 8 weeks,however,there were no difference in weight loss,waist circumference,BMI,body fat,visceral fat area and other metabolic indicators at 8 weeks(P>0.05).Conclusion Both intermittent fasting diet and continuous energy-restricted diet have a similar effect on weight loss and metabolic indexes like blood glucose,HOMA-IR and blood lipid,but intermittent fasting diet can more significantly decrease HDL level.

关 键 词：肥胖 轻断食 低能量饮食 

分 类 号：R58[医药卫生—内分泌]