高G环境下大鼠胫骨的力学性能  

Mechanical properties of rat tibia under high-G environment

作　　者：刘金 高丽兰[1] 彭宇霖 张西正[1,2] Liu Jin;Gao Lilan;Peng Yulin;Zhang Xizheng(Tianjin Key Laboratory of Advanced Electromechanical System Design and Intelligent Control,School of Mechanical Engineering,Tianjin University of Technology,Tianjin 300384,China;Medical Support Technology Institute,Institute of System Engineering,PLA Academy of Military Sciences,Tianjin 300161,China;Second Etching Department of Beijing North Huachuang Microelectronics Equipment Co.,Ltd.,Beijing 100176,China)

机构地区：[1]天津市先进机电系统设计与智能控制重点实验室,天津理工大学机械工程学院,天津市300384 [2]军事科学院系统工程研究院卫勤保障技术研究所,天津市300161 [3]北京北方华创微电子装备有限公司第二刻蚀事业部,北京市100176

出　　处：《中国组织工程研究》2020年第11期1654-1658,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(11572222)，项目负责人：高丽兰;国家自然科学基金项目(11432016)，项目负责人：张西正~~

摘　　要：背景:随着中国航天事业的发展,飞行员面临承受高G力学环境,这种环境会对飞行员骨骼造成严重影响。而胫骨作为最容易发生骨折的骨骼之一,目前对极端力学环境下胫骨生物力学研究较少。目的:通过高G离心加载装置制作动物模型,探究不同高G力学环境对大鼠生长发育和胫骨力学性能的影响。方法:取解放军军事医学科学院实验动物中心提供的雄性Wistar大鼠,通过高G离心加载装置设置悬臂以不同的转速和加速度运行模拟高G环境,并制作动物模型。每周称量大鼠体质量。取大鼠左侧胫骨进行三点弯曲实验,计算胫骨挠度、弹性模量、极限载荷;右侧胫骨进行蠕变实验,在胫骨中段皮质骨表面施加恒定应力并保持3600 s,观察其蠕变应变变化。实验已由天津理工大学动物伦理委员会批准。结果与结论:高G环境会影响大鼠正常生长发育,抑制体质量增长并降低了大鼠胫骨的力学性能,使胫骨的极限挠度分别下降了8.1%,12.2%,37.8%,51.4%;极限载荷分别下降了16%,9%,25.2%,29%。说明极端高G环境会对大鼠产生严重的负面作用。BACKGROUND:With the development of Chinese space industry,pilots are exposed to high-G mechanical environment,which will seriously affect their bones.However,as one of the bones that are most prone to fracture,the biomechanical behavior of the tibia under extreme mechanical environment is rarely reported.OBJECTIVE:To explore the effects of different high-G mechanical environments on the rat growth and development and the mechanical properties of the tibia.METHODS:Male Wistar rats were provided by Laboratory Animal Center of Academy of Military Sciences.The cantilever was set to run at different speeds and accelerations with a high-G centrifugal loading device,and the high-G rat model was made.The rats were weighed weekly.The left tibia of rats was used for undergoing a three-point bending experiment,and the deflection and elastic modulus of the tibia were calculated.The right tibia was subjected to a creep test,and constant stress was applied on the surface of tibial cortical bone and kept 3600 seconds,so as to observe the changes of creep strain.The study was approved by the Laboratory Animal Ethical Committee of Tianjin University of Technology.RESULTS AND CONCLUSION:The high-G environment affected the normal growth and development of rats,inhibited weight gain and reduced the mechanical properties of the tibia,and reduced the limit deflection of the tibia by 8.1%,12.2%,37.8%,and 51.4%,respectively.Limit loads were decreased by 16%,9%,25.2%,and 29%respectively.To conclude,extremely high-G environment exerts serious negative effects on rats.

关 键 词：高G 胫骨 体重 力学性能 三点弯曲 皮质骨 生物力学 组织工程 

分 类 号：R441[医药卫生—诊断学] R85[医药卫生—临床医学]