藏红花醛对大鼠心肌缺血保护作用研究  被引量:6

Protective Effect of Saffranal on Myocardial Ischemia in Rats

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作  者:楚溪[1] 王红芳[1,2] 张园园 张一昕 张建平 CHU Xi;WANG Hong-fang;ZHANG Yuan-yuan;ZHANG Yi-xin;ZHANG Jian-ping(The fourth Hospital of Hebei Medical University,Shijiazhuang 050011)

机构地区:[1]河北医科大学第四医院,石家庄050011 [2]河北中医学院药学院,石家庄050200 [3]河北中医学院基础医学院,石家庄050091

出  处:《河北中医药学报》2019年第6期41-44,共4页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基  金:河北省中医药管理局资助项目:No.2015030

摘  要:目的:研究评价藏红花有效成分藏红花醛对垂体后叶素致急性心肌缺血大鼠生化指标、氧化损伤的作用,初步探讨其机制。方法:50只大鼠随机分为5组(n=10):空白对照组、模型组、阳性药对照组(丹参注射液,5.0 g/kg·d^-1)、藏红花醛高、低剂量组(0.2、0.1 g/kg·d^-1)。阳性药对照组和藏红花醛组大鼠连续7 d腹腔注射丹参注射液和藏红花醛,空白组和模型组大鼠连续7 d腹腔注射生理盐水,末次给药1 h后,除空白对照组外其余各组均舌下静脉注射垂体后叶素。麻醉状态下测定各组大鼠心电图及血流动力学指标,比色法测定血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)及丙二醛(MDA)活性或含量。结果:藏红花醛能明显抑制垂体后叶素所致T波升高、降低血清CK、LDH的活性和MDA的含量,升高SOD活性。结论:藏红花醛能有效缓解垂体后叶素所致大鼠缺血性心肌损伤,其机制可能与抗氧化应激有关。Objective: To study and evaluate the effect of saffranal, an effective component of saffron, on biochemical indexes and oxidative damage in rats with acute myocardial ischemia induced by pituitrin. Methods: Fifty rats were randomly divided into 5 groups (n = 10): blank control group, model group, positive drug control group (Danshen injection, 5.0 g / kg · d^-1), saffranal high and low dose group (0.2, 0.1 g / kg ·d^-1).The rats in the positive control group and saffranal group were injected with Danshen injection and saffranal intraperitoneally for 7 consecutive days, and the rats in the blank group and model group were injected with normal saline intraperitoneally for 7 consecutive days. After the last administration for 1 hour, all groups except the blank control group were injected with Pituitrin into ranine vein. The ECG and hemodynamic indexes were measured under anesthesia. The activity or content of serum creatine kinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured by colorimetry. Results: Saffron could significantly inhibit the T wave increase induced by pituitrin, decrease the activity of serum CK, LDH and MDA, and increase the activity of SOD. Conclusion: saffranal can effectively alleviate the ischemic myocardial injury induced by Pituitrin in rats, and its mechanism may be related to antioxidant stress.

关 键 词:藏红花醛 垂体后叶素 大鼠 心肌缺血 氧化应激 丹参注射液 

分 类 号:R285.5[医药卫生—中药学]

 

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