700名1周岁儿童乙肝抗体检测结果分析  

Analysis of Detection Results of Hepatitis B Antibody in 700 Children Aged 1 Year

作　　者：顾丽[1] 马士化 GU Li;MA Shi-hua(Guanyun County People's Hospital,Guanyun,Jiangsu Province,222200 China;Guanyun County Center for Disease Control and Prevention,Guanyun,Jiangsu Province,222200 China)

机构地区：[1]江苏省灌云县人民医院,江苏灌云222200 [2]江苏省灌云县疾病预防控制中心,江苏灌云222200

出　　处：《系统医学》2019年第22期82-84,共3页Systems Medicine

摘　　要：目的掌握灌云县1周岁儿童乙肝抗体水平,评价新生儿乙肝疫苗的接种效果,为制定乙肝控制策略提供科学依据。方法 2018年10月-2019年2月,随机抽取灌云县辖区内10个接种单位,选取完成乙肝疫苗全程接种的700名1周岁儿童,并按照儿童家长自愿的原则,采集儿童静脉血3~5 mL,分离血清后冷藏送至县疾控中心检测,采用酶联免疫吸附(ELISA))法进行乙肝表面抗体检测。结果共采集700名儿童血样标本,乙肝抗体总阳性率为81.71%(572/700),其中男童、女童乙肝抗体阳性率分别为80.60%(295/366)、82.93%(277/334),两者比较差异无统计学意义(χ^2=0.636,P=0.425>0.05)。抗体阳性率最高的接种单位为杨集中心卫生院,达97.50%(39/40),伊芦卫生院最低,仅为71.88%(23/32),不同接种单位儿童乙肝抗体阳性率比较差异有统计学意义(χ^2=19.773,P=0.019 <0.05)。结论完成全程乙肝疫苗基础免疫后要及时进行乙肝抗体检测,做好乙肝疫苗加强免疫工作和疫苗冷链管理,是提高乙肝抗体阳性率和控制乙肝疫情最有效的措施。Objective To master the hepatitis B antibody level of 1 year old children in Guanyun County,and evaluate the inoculation effect of neonatal hepatitis B vaccine,and provide scientific basis for formulating hepatitis B control strategy.Methods From October 2018 to February 2019,10 inoculation units in the jurisdiction of Guanyun County were randomly selected,and 7001-year-old children who completed the whole process of hepatitis B vaccine were selected.According to the principle of voluntary parents,children's venous blood was collected 3-5ml,serum was separated and sent to the county CDC for testing,and the antibody against hepatitis B was detected by enzyme-linked immunosorbent assay(ELISA).Results A total of 700 children's blood samples were collected.The total positive rate of hepatitis B antibody was 81.71%(572/700).The positive rates of hepatitis B antibody in boys and girls were 80.60%(295/366)and 82.93%(277/334),respectively.The difference was not statistically significant(χ2=0.636,P=0.425>0.05).The highest vaccination unit with positive antibody rate was Yangji Central Health Center,which was 97.50%(39/40),and the lowest in Yilu Health Center,only 71.88%(23/32).The positive rate of hepatitis B antibody in children with different vaccination units was statistically significant(χ2=19.773,P=0.019<0.05).Conclusion It is necessary to timely test hepatitis B antibody after completing the basic immunization of hepatitis B vaccine.It is the most effective measure to improve the positive rate of hepatitis B antibody and control hepatitis B epidemic.

关 键 词：儿童 乙肝抗体 乙肝 

分 类 号：R446.6[医药卫生—诊断学] R725.1[医药卫生—临床医学]