女性生殖道解脲脲原体感染及耐药性分析  

Analysis of prevalence of ureaplasma urealyticum infection and drug resistance in female genital tracts

作　　者：郑杰 郭彦言[2] 徐建余 ZHENG Jie;GUO Yanyan;XU Jianyu(North China University of Science and Technology,Tangshan,063000,China)

机构地区：[1]华北理工大学,河北唐山063000 [2]唐山工人医院检验科 [3]华北理工大学生命科学学院

出　　处：《华北理工大学学报（医学版）》2019年第6期471-475,共5页Journal of North China University of Science and Technology：Health Sciences Edition

摘　　要：①目的分析女性生殖道解脲脲原体(Uu)的感染情况及耐药分析。②方法采用众爱生河北生物科技有限公司生产的试剂盒,对临床收集的1045例样本进行培养鉴定及体外药物敏感实验。③结果本市被检测的1045例女性患者中,检测为支原体感染阳性患者566例,其中以单一Uu感染患者居多,共检出432例,占阳性患者76.33%,总检出率为41.34%;其次为解脲脲原体Uu和人型支原体Mh的混合感染,共检出108例,占阳性患者19.08%;而单纯Mh感染患者最少,仅有26例。Uu耐药情况最严重的为喹诺酮类药物,耐药率最高的为诺氟沙星,高达90.74%。其他药物耐药率依次为壮观霉素(90.28%)、氧氟沙星(88.43%)、环丙沙星(86.5%)、司帕沙星(32.64%)、左氧氟沙星(30.09%)。大环内酯类耐药率为克拉霉素(20.83)%、罗红霉素(13.89%)、阿奇霉素(12.04%)和交沙霉素(3.24%)。四环素类药物耐药情况为多西环素(2.31%)和米诺环素(1.39%)。④结论女性生殖道感染患者的解脲脲原体感染率较高,以单纯Uu感染为主。女性生殖道Uu耐药形式比较严重,尤其是喹诺酮类药物情况最为严峻。体外药物敏感实验对临床治疗Uu感染具有重要的指导意义,目前治疗应首选多西环素和米诺环素可提高临床治愈率。Objective To analyze the infection and drug resistance of mycoplasma urealyticum in female reproductive tract.Methods The culture and identification of 1045 clinical samples and in vitro drug sensitivity experiments were carried out using the kit produced by zhongaisheng hebei biotechnology co.,LTD.Results Among the 1045 female patients being corrected by the city's gynecologists,566 were tested positive for mycoplasma infection,among which the majority were single Uu infection patients,with a total of 432 cases detected,accounting for 76.33%of the positive patients and the total detection rate of 41.34%.Secondly,the mixed infection of Uu+Mh was detected in 108 cases,accounting for 19.08%of the positive patients.However,the patients with pure Mh infection were the least,only 26 cases.Quinolones had the most serious drug resistance in Uu,and norfloxacin had the highest drug resistance rate,up to 90.74%.The drug resistance rates of other drugs were successively as follows:guanamycin(90.28%),ofloxacin(88.43%),ciprofloxacin(86.5%),sparfloxacin(32.64%),levofloxacin(30.09%).The drug resistance rate of macrolide was 20.83%,13.89%,12.04%and 3.24%respectively.The drug resistance of tetracycline was doxycycline(2.31%)and minocycline(1.39%).Conclusion The infection rate of ureaplasma urealyticum in female genital tract infection patients is high,and the main infection is Uu infection.Female genital tract Uu drug resistance form is quite serious,especially quinolones drug situation is the most serious.In vitro drug sensitivity test has important guiding significance for the clinical treatment of Uu infection.Currently,doxycycline and minocycline should be the first choice for treatment to improve the clinical cure rate.

关 键 词：解脲支原体 生殖道感染 耐药 

分 类 号：R587[医药卫生—内分泌]