药物输送体系构筑中的超分子组装策略  

Supramolecular Self-Assembly Applied for the Design of Drug Delivery Systems

作　　者：徐子悦 张运昌 林佳乐 王辉[1] 张丹维[1] 黎占亭[1] Zi-Yue Xu;Yun-Chang Zhang;Jia-Le Lin;Hui Wang;Dan-Wei Zhang;Zhan-Ting Li(School of Chemistry,Fudan University,Shanghai 200438,China)

机构地区：[1]复旦大学化学系

出　　处：《化学进展》2019年第11期1540-1549,共10页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21890732,21921003)资助~~

摘　　要：超分子组装提供了药物输送体系设计的新原理。以高效的分子间非共价键作用为驱动力,超分子药物输送体系能够利用结构简单的分子单体获得精确的成分控制,并使得载体结构易于预测,形貌与体积易于调控,有利于实现药物的控制释放。本文首先总结超分子药物输送体系的研究背景,之后重点介绍基于环糊精、杯芳烃、柱芳烃和葫芦脲的主-客体体系的超分子药物输送体系的构建与药物输送功能,然后介绍水溶性的超分子有机框架在药物输送方面的应用,最后提出了超分子药物载体实用化需要克服的若干挑战性问题。Supramolecular self-assembly provides a new strategy for the development of drug delivery systems from molecular components.With non-covalent interactions as driving forces,supramolecular drug delivery systems(SDDSs)can realize precise component control at the molecular level,increased predictability of the self-assembled structures,tunable control of morphologies and sizes,controlled release of delivered drugs.In this review,we first concisely introduce the background for the design of SDDSs and then describe important advances in SDDS development that involves the applications of cyclodextrin,calixarene,pillararene and cucurbituril based on host-guest interactions.Following these popular design principles,we further present the applications of water-soluble supramolecular organic frameworks as SDDSs.Finally,the challenges that need to be addressed for the practical translation of SDDSs are discussed.

关 键 词：超分子 药物输送 主客体作用 自组装 抗肿瘤药物 

分 类 号：O641.3[理学—物理化学] O62[理学—化学]