促皮质素治疗肾小球疾病研究进展  

Progress on treating of glomerular diseases with adrenocorticotrophic hormone

作　　者：张莉[1] 张建江[1] Zhang Li;Zhang Jianjiang(Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Clinical Center of Pediatric Nephrology of Henan Province,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院儿科,河南省儿童肾脏病临床诊疗中心,450052

出　　处：《中华实用儿科临床杂志》2019年第23期1837-1840,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：促皮质素是一种垂体神经免疫内分泌多肽,属黑皮质素系统.肾小球疾病在儿童肾脏疾病较多见,且有进展为肾功能不全甚至肾衰竭的可能.目前应用促皮质素治疗肾小球疾病是研究热点.促皮质素对足细胞有保护作用,并具有抗尿蛋白、降脂的作用.促皮质素可能通过类固醇机制和非类固醇机制发挥上述作用.现就ACTH治疗肾小球疾病的种类、机制及研究进展作一综述.Adrenocorticotrophic hormone(ACTH)is a pituitary neuroimmunoendocrine polypeptide that belongs to the melanocortin system.Glomerular disease is common in children with kidney disease and may progress to renal insufficiency or even renal failure.The application of ACTH in the treatment of glomerular disease is a hot topic.Studies have shown that ACTH has a significant protective effect on podocytes,and plays a role in anti-urine protein and lipid-lowering.ACTH may play these roles through steroid and non-steroid mechanisms.This article reviews the types,mechanism and study progress of ACTH in the treatment of glomerular disease.

关 键 词：促皮质素 肾小球疾病 机制 研究进展 

分 类 号：R726[医药卫生—儿科] R692[医药卫生—临床医学]