中间体衍生化法与新农药创制——杀线虫剂Fluazaindolizine的创制经纬分析  

The Intermediate Derivatization Method and Novel Agrochemical Discovery——The Discovery of Nematicide Fluazaindolizine

作　　者：李淼 杨吉春 吴峤 刘长令 LI Miao;YANG Ji-chun;WU Qiao;LIU Chang-ling(State Key Laboratory of the Discovery and Development of Novel Pesticide,Shenyang Sinochem Agrochemicals R&D Co,Ltd,Shenyang 110021,China)

机构地区：[1]沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室

出　　处：《农药》2019年第12期859-863,共5页Agrochemicals

摘　　要："中间体衍生化法"是针对农药创制难度大、成功率低创建的方法,利用该方法已发现多个安全、高效的绿色农药品种。通过对杀线虫剂fluazaindolizine的创制经纬进行分析,从"中间体衍生化法"的角度说明新药创制过程中选择和利用合适中间体的重要性,也进一步说明了"中间体衍生化法"具有普适性,可大幅提高新农药创制的成功率。"The intermediate derivatization method"was established aiming at the characteristics of great difficulty and low success rate in the discovery and development of novel agrochemicals,and some safe and efficient products were successfully discovered by using this method. This paper summarized the discovery of fluazindolizine and demonstrated the importance of selecting and using suitable intermediates in the discovery of novel agrochemicals from the perspective of "the intermediate derivatization method"and further showed this method is universal. The success rate of new pesticide creation can be greatly improved by using this method.

关 键 词：中间体衍生化法 新农药创制 fluazaindolizine 中间体 

分 类 号：TQ460[化学工程—制药化工]