由1,1-二溴烯烃一锅法合成1,4-二取代-1,2,3-三氮唑  

One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from 1,1-Dibromoalkenes

作　　者：苏长会 刘霞[2] 潘涛[2] 沈宏[2] 黄兆琴[2] Su Changhui;Liu Xia;Pan Tao;Shen Hong;Hang Zhaoqin(School of Chemistry and Life Science,Nanjing University Jinling College,Nanjing 210089;College of Environment Science and Ecology,Jiangsu Open University,Nanjing 210036)

机构地区：[1]南京大学金陵学院化学与生命科学学院,南京210089 [2]江苏开放大学环境生态学院,南京210036

出　　处：《化学通报》2019年第12期1130-1133,1058,共5页Chemistry

基　　金：江苏省高校自然科学基金项目(16KJB150007);江苏开放大学十三五规划课题(17SSW-Z-Y-023),江苏开放大学“纳米功能材料研发及环保应用研究团队”项目(102916101)资助

摘　　要：以1,1-二溴烯烃和芳基叠氮化合物为原料,碘化亚铜为催化剂,室温下通过一锅法合成了1,4-二取代-1,2,3-三氮唑衍生物。通过IR、MS、1H NMR及13C NMR等对目标产物结构进行确证。考察了催化剂用量、反应溶剂、反应温度对产品收率的影响,并提出了可能的反应机理。该合成方法具有环境友好、条件温和、操作简单、收率高等特点。1,4-Disubstituted 1,2,3-triazoles were synthesized by a Cu I catalyzed one-pot reaction using 1,1-dibromoalkenes and aryl azides as raw materials under room temperature. The structures of target compounds were characterized by IR,MS,1 H NMR and13 C NMR spectroscopy. Effects of the amount of catalyst,solvent and the reaction temperature on the yields of product were studied,and the possible reaction mechanism was proposed. This method has the advantages of environment friendly,mild reaction conditions,simple one pot operation and high yield.

关 键 词：1 1-二溴烯烃 一锅法合成 1 2 3-三氮唑 杂环化合物 

分 类 号：TQ460.1[化学工程—制药化工]